NK2 homeobox 1

NKX2-1
Identifiers
Aliases	NKX2-1, Nkx2-1, AV026640, Nkx2.1, T/EBP, Titf1, Ttf-1, BCH, BHC, NK-2, NKX2A, TEBP, TTF1, NMTC1, NK2 homeobox 1
External IDs	OMIM: 600635; MGI: 108067; HomoloGene: 2488; GeneCards: NKX2-1; OMA:NKX2-1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	36,521,149 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	56,583,693 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; lower lobe of lung; ; right lung; ; upper lobe of lung; ; upper lobe of left lung; ; buccal mucosa cell; ; epithelium of bronchus; ; bronchial epithelial cell; ; visceral pleura;
	Top expressed in
	thyroid gland; ; urethra; ; male urethra; ; hair; ; pituitary stalk; ; main bronchus; ; tongue; ; epithelium of trachea; ; left lung lobe; ; embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; protein binding; enzyme binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; intronic transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	nucleoplasm; nucleus; transcription regulator complex;
Biological process	regulation of transcription, DNA-templated; rhythmic process; negative regulation of transforming growth factor beta receptor signaling pathway; transcription, DNA-templated; positive regulation of gene expression; negative regulation of cell migration; response to hormone; forebrain development; epithelial tube branching involved in lung morphogenesis; negative regulation of epithelial to mesenchymal transition; negative regulation of transcription by RNA polymerase II; neuron migration; regulation of transcription by RNA polymerase II; phospholipid metabolic process; pattern specification process; axon guidance; brain development; endoderm development; locomotory behavior; animal organ morphogenesis; telencephalon development; globus pallidus development; hippocampus development; cerebral cortex cell migration; forebrain dorsal/ventral pattern formation; forebrain neuron fate commitment; forebrain neuron differentiation; cerebral cortex GABAergic interneuron differentiation; cerebral cortex neuron differentiation; pituitary gland development; telencephalon cell migration; lung development; thyroid gland development; developmental induction; Leydig cell differentiation; positive regulation of circadian rhythm; negative regulation of transcription, DNA-templated; positive regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; anatomical structure formation involved in morphogenesis; neuron fate commitment; oligodendrocyte differentiation; lung saccule development; club cell differentiation; type II pneumocyte differentiation; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	7080
	21869
	ENSG00000136352
	ENSMUSG00000001496
	P43699
	P50220
	NM_001079668; NM_003317
	NM_001146198; NM_009385
	NP_001073136; NP_003308
	NP_033411; NP_001390509
	Wikidata
View/Edit Human	View/Edit Mouse

NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene.