NKX2-2

NKX2-2
Identifiers
Aliases	NKX2-2, NKX2.2, NKX2B, NK2 homeobox 2
External IDs	OMIM: 604612; MGI: 97347; HomoloGene: 1879; GeneCards: NKX2-2; OMA:NKX2-2 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	21,514,064 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	147,194,243 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; subthalamic nucleus; ; Medulla Oblongata; ; superior vestibular nucleus; ; ventral tegmental area; ; inferior olivary nucleus; ; spinal cord; ; C1 segment; ; external globus pallidus; ; pars reticulata;
	Top expressed in
	islet of Langerhans; ; lumbar subsegment of spinal cord; ; optic nerve; ; central gray substance of midbrain; ; ventral nucleus of lateral geniculate body; ; embryo; ; anterior horn of spinal cord; ; nucleus of stria terminalis; ; Hypothalamus; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; transcription factor binding; chromatin binding; transcription coactivator activity; cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	intracellular anatomical structure; nucleoplasm; nucleus;
Biological process	positive regulation of oligodendrocyte differentiation; cell differentiation; regulation of transcription, DNA-templated; negative regulation of neuron differentiation; pancreatic PP cell fate commitment; response to organic cyclic compound; cell development; spinal cord oligodendrocyte cell fate specification; response to progesterone; neuron fate specification; response to glucose; transcription, DNA-templated; nervous system development; multicellular organism development; brain development; astrocyte differentiation; positive regulation of gene expression; positive regulation of neuron differentiation; positive regulation of cell differentiation; regulation of cell differentiation; smoothened signaling pathway; oligodendrocyte development; spinal cord motor neuron differentiation; digestive tract development; pancreatic A cell fate commitment; type B pancreatic cell fate commitment; ventral spinal cord interneuron fate determination; type B pancreatic cell development; spinal cord oligodendrocyte cell differentiation; optic nerve development; positive regulation of transcription by RNA polymerase II; positive regulation of DNA-binding transcription factor activity; endocrine pancreas development;
	Sources:Amigo / QuickGO
Orthologs
	4821
	18088
	ENSG00000125820
	ENSMUSG00000027434
	O95096
	P42586
	NM_002509
	NM_001077632; NM_010919
	NP_002500
	NP_001071100; NP_035049
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Nkx-2.2 is a protein that in humans is encoded by the NKX2-2 gene.

Homeobox protein Nkx-2.2 contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.

The expression of Nkx2-2 is regulated by an antisense RNA called Nkx2-2as.

In the developing spinal cord, Nkx-2.2 regulates IRX3 thereby contributing to the proper differentiation of the ventral horn neurons.