NKX3-1

NKX3-1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L9R
Identifiers
Aliases	NKX3-1, BAPX2, NKX3, NKX3.1, NKX3A, NK3 homeobox 1
External IDs	OMIM: 602041; MGI: 97352; HomoloGene: 4494; GeneCards: NKX3-1; OMA:NKX3-1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	23,682,938 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	69,432,111 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; secondary oocyte; ; sperm; ; prostate; ; trachea; ; germinal epithelium; ; urethra; ; testicle; ; mucosa of nose; ; minor salivary glands;
	Top expressed in
	prostatic epithelium; ; vasculature of trunk; ; urethral gland (male); ; bulbo-urethral gland; ; descending aorta; ; renal artery; ; dorsal aorta; ; anterior lobe of prostate; ; gastrula; ; incisor;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; transcription factor binding; histone deacetylase binding; transcription cis-regulatory region binding; RNA polymerase II general transcription initiation factor activity; estrogen receptor activity; protein kinase activator activity; protein self-association; MADS box domain binding; protein binding; cysteine-type endopeptidase activator activity involved in apoptotic process; estrogen receptor binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; nuclear receptor activity;
Cellular component	intracellular anatomical structure; nucleus; site of DNA damage;
Biological process	somitogenesis; androgen receptor signaling pathway; cellular response to steroid hormone stimulus; dorsal aorta development; positive regulation of protein phosphorylation; male gonad development; positive regulation of cell death; regulation of transcription, DNA-templated; protein kinase B signaling; response to testosterone; epithelial cell proliferation involved in salivary gland morphogenesis; cellular response to tumor necrosis factor; positive regulation of androgen secretion; positive regulation of mitotic cell cycle; positive regulation of apoptotic signaling pathway; prostate gland development; negative regulation of gene expression; transcription, DNA-templated; multicellular organism development; positive regulation of transcription, DNA-templated; salivary gland development; heart development; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of gene expression; positive regulation of response to DNA damage stimulus; branching involved in prostate gland morphogenesis; negative regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of cell population proliferation; cellular response to interleukin-1; negative regulation of epithelial cell proliferation; negative regulation of insulin-like growth factor receptor signaling pathway; urogenital system development; positive regulation of phosphatidylinositol 3-kinase signaling; metanephros development; negative regulation of transcription, DNA-templated; activation of cysteine-type endopeptidase activity involved in apoptotic process; branching morphogenesis of an epithelial tube; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of cell division; cellular response to hypoxia; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; negative regulation of mitotic cell cycle; pharyngeal system development; activation of protein kinase activity; regulation of protein localization; positive regulation of DNA-binding transcription factor activity; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	4824
	18095
	ENSG00000167034
	ENSMUSG00000022061
	Q99801
	P97436
	NM_001256339; NM_006167
	NM_010921
	NP_001243268; NP_006158
	NP_035051
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Nkx-3.1, also known as NKX3-1, NKX3, BAPX2, NKX3A and NKX3.1 is a protein that in humans is encoded by the NKX3-1 gene located on chromosome 8p. NKX3-1 is a prostatic tumor suppressor gene.

NKX3-1 is an androgen-regulated, prostate-specific homeobox gene whose expression is predominantly localized to prostate epithelium. It acts as a transcription factor that has critical function in prostate development and tumor suppression. It is a negative regulator of epithelial cell growth in prostate tissue. The NKX3-1 homeobox protein is encoded by the NKX3-1 gene.