NKX3-2

NKX3-2
Identifiers
Aliases	NKX3-2, NK3 homeobox 2, BAPX1, NKX3.2, NKX3B, SMMD
External IDs	OMIM: 602183; MGI: 108015; HomoloGene: 68168; GeneCards: NKX3-2; OMA:NKX3-2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	13,544,508 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	41,921,844 bp
RNA expression pattern
	Top expressed in
	tibia; ; muscle layer of sigmoid colon; ; cartilage tissue; ; tendon of biceps brachii; ; transverse colon; ; gonad; ; spleen; ; smooth muscle tissue; ; embryo; ; rectum;
	Top expressed in
	sclerotome; ; female urethra; ; male urethra; ; embryo; ; somite; ; lateral plate mesoderm; ; embryo; ; primordial pancreas; ; Meckel's cartilage; ; vertebra;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity;
Cellular component	nucleus;
Biological process	animal organ development; skeletal system development; regulation of transcription, DNA-templated; digestive system development; intestinal epithelial cell development; skeletal system morphogenesis; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; spleen development; transcription by RNA polymerase II; transcription, DNA-templated; embryonic skeletal system development; animal organ formation; determination of left/right symmetry; negative regulation of chondrocyte differentiation; middle ear morphogenesis; pancreas development; cell differentiation; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	579
	12020
	ENSG00000109705
	ENSMUSG00000049691
	P78367
	P97503
	NM_001189
	NM_007524
	NP_001180
	NP_031550
	Wikidata
View/Edit Human	View/Edit Mouse

NK3 homeobox 2 also known as NKX3-2 is a human gene. It is a homolog of bagpipe (bap) in Drosophila and therefore also known as Bapx1 (bagpipe homeobox homolog 1). The protein encoded by this gene is a homeodomain containing transcription factor.