NKX6-1

NKX6-1
Identifiers
Aliases	NKX6-1, NKX6.1, NKX6A, NK6 homeobox 1
External IDs	OMIM: 602563; MGI: 1206039; HomoloGene: 4495; GeneCards: NKX6-1; OMA:NKX6-1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	84,499,292 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	101,812,862 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; islet of Langerhans; ; testicle; ; body of pancreas; ; stromal cell of endometrium; ; left lobe of thyroid gland; ; substantia nigra; ; left testis; ; Hypothalamus; ; right testis;
	Top expressed in
	islet of Langerhans; ; primordial pancreas; ; stria vascularis; ; embryo; ; facial motor nucleus; ; esophagus; ; spinal cord; ; anterior horn of spinal cord; ; vestibular membrane of cochlear duct; ; cochlea;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; chromatin binding; DNA-binding transcription factor activity; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; extracellular exosome;
Biological process	smoothened signaling pathway; detection of glucose; pancreas development; transcription, DNA-templated; regulation of axon extension; multicellular organism development; cellular response to peptide hormone stimulus; central nervous system neuron differentiation; response to nicotine; negative regulation of glial cell differentiation; type B pancreatic cell proliferation; cellular response to cytokine stimulus; positive regulation of DNA-binding transcription factor activity; neurogenesis; regulation of transcription by RNA polymerase II; type B pancreatic cell development; positive regulation of neuron differentiation; negative regulation of transcription by RNA polymerase II; positive regulation of type B pancreatic cell development; type B pancreatic cell maturation; oligodendrocyte differentiation; regulation of transcription, DNA-templated; cell population proliferation; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; positive regulation of glial cell differentiation; cell differentiation; positive regulation of insulin secretion; animal organ morphogenesis; regulation of neuron migration; neuron migration; regulation of insulin secretion; endocrine pancreas development; type B pancreatic cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	4825
	18096
	ENSG00000163623
	ENSMUSG00000035187
	P78426
	Q99MA9
	NM_006168
	NM_144955
	NP_006159
	NP_659204
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.