NLGN4X

NLGN4X
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2WQZ, 2XB6, 3BE8
Identifiers
Aliases	NLGN4X, ASPGX2, AUTSX2, HLNX, HNL4X, NLGN4, neuroligin 4, X-linked, neuroligin 4 X-linked
External IDs	OMIM: 300427; HomoloGene: 136297; GeneCards: NLGN4X; OMA:NLGN4X - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	6,228,867 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; spinal ganglia; ; cerebellar vermis; ; entorhinal cortex; ; ventricular zone; ; secondary oocyte; ; decidua; ; Brodmann area 46; ; buccal mucosa cell;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; scaffold protein binding; carboxylic ester hydrolase activity; neurexin family protein binding; protein binding; chloride ion binding; cell adhesion molecule binding; signaling receptor activity;
Cellular component	integral component of membrane; postsynaptic membrane; membrane; postsynaptic density; synapse; integral component of plasma membrane; excitatory synapse; cell surface; cell junction; dendrite; plasma membrane; intracellular anatomical structure; spanning component of membrane; presynapse; symmetric, GABA-ergic, inhibitory synapse; asymmetric, glutamatergic, excitatory synapse;
Biological process	cell-cell junction organization; organ growth; neuron cell-cell adhesion; brainstem development; synapse organization; learning; cerebellum development; negative regulation of excitatory postsynaptic potential; presynaptic membrane assembly; vocalization behavior; adult behavior; cell adhesion; neuron differentiation; social behavior; synaptic vesicle endocytosis; postsynaptic membrane assembly; modulation of chemical synaptic transmission; presynapse assembly;
	Sources:Amigo / QuickGO
Orthologs
	57502
	n/a
	ENSG00000146938
	n/a
	Q8N0W4
	n/a
	NM_001282145; NM_001282146; NM_020742; NM_181332
	n/a
	NP_001269074; NP_001269075; NP_065793; NP_851849
	n/a
	Wikidata
View/Edit Human

Neuroligin-4, X-linked is a protein that in humans is encoded by the NLGN4X gene.

In the human brain, the synaptic protein NLGN4 is primarily expressed in the cerebral cortex.

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligins may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs, large (Drosophila) homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Two transcript variants encoding the same protein have been identified for this gene.