NLRC4

NLRC4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4KXF
Identifiers
Aliases	NLRC4, CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, IPAF, AIFEC, FCAS4, NLR family, CARD domain containing 4, NLR family CARD domain containing 4
External IDs	OMIM: 606831; MGI: 3036243; HomoloGene: 10924; GeneCards: NLRC4; OMA:NLRC4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	32,265,732 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	74,766,137 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; gonad; ; trabecular bone; ; testicle; ; bone marrow; ; bone marrow cells; ; spleen; ; appendix;
	Top expressed in
	jejunum; ; ileum; ; zygote; ; duodenum; ; colon; ; secondary oocyte; ; primary oocyte; ; proximal tubule; ; spleen; ; stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; protein homodimerization activity; ubiquitin-protein transferase activity; protein binding; ATP binding; magnesium ion binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; identical protein binding;
Cellular component	cytoplasm; cytosol; intracellular anatomical structure; IPAF inflammasome complex; nucleus;
Biological process	pyroptosis; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; immune system process; regulation of cysteine-type endopeptidase activity involved in apoptotic process; mitotic spindle assembly; regulation of signal transduction; defense response to bacterium; positive regulation of NF-kappaB transcription factor activity; detection of bacterium; activation of innate immune response; positive regulation of apoptotic process; inflammatory response; protein homooligomerization; activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; protein ubiquitination; regulation of apoptotic process; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	58484
	268973
	ENSG00000091106
	ENSMUSG00000039193
	Q9NPP4
	Q3UP24
	NM_001199138; NM_001199139; NM_001302504; NM_021209
	NM_001033367
	NP_001186067; NP_001186068; NP_001289433; NP_067032
	NP_001028539
	Wikidata
View/Edit Human	View/Edit Mouse

NLR family CARD domain-containing protein 4 is a protein that in humans is encoded by the NLRC4 gene.