NLRC5

NLRC5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MJM
Identifiers
Aliases	NLRC5, CLR16.1, NOD27, NOD4, NLR family, CARD domain containing 5, NLR family CARD domain containing 5
External IDs	OMIM: 613537; MGI: 3612191; HomoloGene: 88935; GeneCards: NLRC5; OMA:NLRC5 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	57,083,531 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	95,253,900 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; spleen; ; bone marrow cells; ; blood; ; appendix; ; lymph node; ; monocyte; ; mucosa of ileum; ; trabecular bone; ; epithelium of nasopharynx;
	Top expressed in
	mesenteric lymph nodes; ; subcutaneous adipose tissue; ; blood; ; spleen; ; submandibular gland; ; thymus; ; Paneth cell; ; lens; ; white adipose tissue; ; skin of abdomen;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; protein binding; ATP binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	cytoplasm; centrosome; nucleus; cytosol;
Biological process	positive regulation of type I interferon-mediated signaling pathway; negative regulation of type I interferon production; positive regulation of interferon-gamma-mediated signaling pathway; positive regulation of MHC class I biosynthetic process; positive regulation of transcription by RNA polymerase II; regulation of kinase activity; immune system process; innate immune response; negative regulation of NF-kappaB transcription factor activity; negative regulation of type I interferon-mediated signaling pathway; response to bacterium; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	84166
	434341
	ENSG00000140853
	ENSMUSG00000074151
	Q86WI3
	C3VPR6
	NM_032206; NM_001330552
	NM_001033207
	NP_001317481; NP_115582
	NP_001028379
	Wikidata
View/Edit Human	View/Edit Mouse

NLRC5, short for NOD-like receptor family CARD domain containing 5, is an intracellular protein that plays a role in the immune system. NLRC5 is a pattern recognition receptor implicated in innate immunity to viruses potentially by regulating interferon activity. It also acts as an innate immune sensor to drive inflammatory cell death, PANoptosis. In humans, the NLRC5 protein is encoded by the NLRC5 gene. It has also been called NOD27, NOD4, and CLR16.1.