NOD-like receptor family pyrin domain containing 11 is a protein that in humans is encoded by the NLRP11 gene located on the long arm of human chromosome 19q13.42. NLRP11 belongs to the NALP subfamily, part of a large subfamily of CATERPILLER. It is also known as NALP11, PYPAF6, NOD17, PAN10, and CLR19.6
Being a member of the NOD-like receptor protein (NLRP) gene family, it encodes a protein with an N-terminal pyrin death (PYD) domain and nucleoside triphosphate hydrolase (NACHT) domain and a C-terminal leucine-rich repeats (LRR) region. This gene regulates caspases in the proinflammatory signal transduction pathway. Based on studies of other members of the NLRP gene family with similar domain structures, it is predicted to form part of the multiprotein inflammasome complex.
NLRP11 is expressed mainly in immune cells, B cells, myeloid cells, and B cell lymphoma cell lines. NLRP11 is involved in the regulation of inflammatory responses in human cells.
NALPs family controls cytokines, inflammatory responses, NF-κB activation, and likely cell death and survival.
