NNT (gene)

NNT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DJL, 1PT9, 1U31
Identifiers
Aliases	NNT, GCCD4, nicotinamide nucleotide transhydrogenase
External IDs	OMIM: 607878; MGI: 109279; HomoloGene: 7445; GeneCards: NNT; OMA:NNT - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	43,707,405 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	119,545,533 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; muscle of thigh; ; biceps brachii; ; thoracic diaphragm; ; left ventricle; ; right auricle of heart; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; gastrocnemius muscle; ; vastus lateralis muscle;
	Top expressed in
	right kidney; ; granulocyte; ; muscle of thigh; ; tail of embryo; ; ventricular zone; ; genital tubercle; ; yolk sac; ; urethra; ; embryo; ; neural tube;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; NAD binding; NAD(P)+ transhydrogenase (AB-specific) activity; NAD(P)+ transhydrogenase (B-specific) activity; NAD(P)+ transhydrogenase activity; NADP binding;
Cellular component	integral component of membrane; mitochondrial inner membrane; membrane; mitochondrion; mitochondrial respirasome;
Biological process	reactive oxygen species metabolic process; tricarboxylic acid cycle; NADPH regeneration; proton transmembrane transport; negative regulation of protein phosphorylation; positive regulation of mitochondrial membrane potential; oxygen homeostasis; response to vitamin; negative regulation of apoptotic process; cell redox homeostasis; cellular oxidant detoxification; positive regulation of hydrogen peroxide catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	23530
	18115
	ENSG00000112992
	ENSMUSG00000025453
	Q13423
	Q61941
	NM_012343; NM_182977; NM_001331026
	NM_008710; NM_001308506
	NP_001317955; NP_036475; NP_892022
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

NAD(P) transhydrogenase, mitochondrial is an enzyme that in humans is encoded by the NNT gene on chromosome 5.

The NNT gene contains 26 exons and encodes a transhydrogenase protein that is ~109 kDa in molecular weight and is involved in antioxidant defense in the mitochondria. Two alternatively spliced variants, encoding the same protein, have been found for this gene.