NOD2

NOD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5IRL, 5IRM, 5IRN
Identifiers
Aliases	NOD2, ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1, nucleotide binding oligomerization domain containing 2, BLAUS, YAOS
External IDs	OMIM: 605956; MGI: 2429397; HomoloGene: 11156; GeneCards: NOD2; OMA:NOD2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	50,734,041 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	89,415,102 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; skin of leg; ; skin of abdomen; ; vulva; ; human penis; ; cartilage tissue; ; bone marrow cells; ; vagina;
	Top expressed in
	granulocyte; ; secondary oocyte; ; primary oocyte; ; zygote; ; embryo; ; esophagus; ; zone of skin; ; lip; ; quadriceps femoris muscle; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	Hsp90 protein binding; nucleotide binding; Hsp70 protein binding; protein binding; peptidoglycan binding; enzyme binding; actin binding; CARD domain binding; ATP binding; protein kinase binding; muramyl dipeptide binding; protein-containing complex binding;
Cellular component	cytoplasm; cytosol; vesicle; membrane; plasma membrane; cell surface; basolateral plasma membrane; COP9 signalosome; cytoskeleton; Golgi apparatus; mitochondrion; protein-containing complex;
Biological process	positive regulation of prostaglandin-endoperoxide synthase activity; regulation of apoptotic process; defense response; detection of biotic stimulus; cytokine production involved in immune response; positive regulation of cytokine production involved in inflammatory response; intracellular signal transduction; detection of muramyl dipeptide; positive regulation of interleukin-10 production; positive regulation of epithelial cell proliferation; immune system process; positive regulation of oxidoreductase activity; response to muramyl dipeptide; positive regulation of prostaglandin-E synthase activity; positive regulation of JNK cascade; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of NIK/NF-kappaB signaling; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of gamma-delta T cell activation; cellular response to muramyl dipeptide; JNK cascade; negative regulation of macrophage apoptotic process; positive regulation of dendritic cell antigen processing and presentation; nucleotide-binding oligomerization domain containing 2 signaling pathway; maintenance of gastrointestinal epithelium; defense response to bacterium; positive regulation of NF-kappaB transcription factor activity; positive regulation of interleukin-8 production; detection of bacterium; positive regulation of interleukin-1 beta production; regulation of inflammatory response; positive regulation of interleukin-6 production; protein complex oligomerization; positive regulation of tumor necrosis factor production; positive regulation of ERK1 and ERK2 cascade; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of B cell activation; positive regulation of interleukin-17 production; positive regulation of type 2 immune response; nucleotide-binding oligomerization domain containing signaling pathway; positive regulation of stress-activated MAPK cascade; positive regulation of Notch signaling pathway; positive regulation of transcription by RNA polymerase II; cellular response to organic cyclic compound; positive regulation of cell population proliferation; innate immune response; response to nutrient; positive regulation of dendritic cell cytokine production; positive regulation of protein K63-linked ubiquitination; cellular response to peptidoglycan; positive regulation of MAP kinase activity; interleukin-1-mediated signaling pathway; cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	64127
	257632
	ENSG00000167207
	ENSMUSG00000055994
	Q9HC29
	Q80SY9
	NM_001293557; NM_022162; NM_001370466
	NM_145857
	NP_001280486; NP_071445; NP_001357395
	NP_665856
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleotide-binding oligomerization domain-containing protein 2 (NOD2), also known as caspase recruitment domain-containing protein 15 (CARD15) or inflammatory bowel disease protein 1 (IBD1), is a protein that in humans is encoded by the NOD2 gene located on chromosome 16. NOD2 plays an important role in the immune system. It recognizes bacterial molecules (peptidoglycans) and stimulates an immune reaction.

NOD2 is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants and recognizes molecules containing the specific structure called muramyl dipeptide (MDP) that is found in certain bacteria.