NOL3

NOL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UZ0
Identifiers
Aliases	NOL3, ARC, FCM, MYP, NOP, NOP30, nucleolar protein 3, MYOCL1
External IDs	OMIM: 605235; MGI: 1925938; HomoloGene: 31208; GeneCards: NOL3; OMA:NOL3 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	67,175,735 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	106,008,571 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; gastrocnemius muscle; ; skin of abdomen; ; right adrenal gland; ; right adrenal cortex; ; skin of leg; ; left adrenal gland; ; body of pancreas; ; muscle of thigh; ; left adrenal cortex;
	Top expressed in
	lumbar spinal ganglion; ; extraocular muscle; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; digastric muscle; ; ankle; ; muscle of thigh; ; thoracic diaphragm; ; right ventricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	death effector domain binding; calcium ion binding; death receptor binding; metal ion binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein binding; RNA binding; identical protein binding; signaling receptor binding; caspase binding;
Cellular component	cytosol; membrane; sarcoplasmic reticulum; sarcoplasm; nucleus; mitochondrion; nucleolus; cytoplasm;
Biological process	regulation of apoptotic process; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; response to hypoxia; negative regulation of striated muscle cell apoptotic process; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of tumor necrosis factor-mediated signaling pathway; negative regulation of muscle atrophy; negative regulation of release of cytochrome c from mitochondria; response to injury involved in regulation of muscle adaptation; negative regulation of extrinsic apoptotic signaling pathway; mRNA processing; negative regulation of apoptotic process; cardiac muscle cell apoptotic process; intrinsic apoptotic signaling pathway; negative regulation of cardiac muscle cell apoptotic process; blood vessel remodeling; response to ischemia; mRNA splice site selection; protein complex oligomerization; negative regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of gene expression; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of necrotic cell death; apoptotic process; RNA splicing; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologs
	8996
	78688
	ENSG00000140939
	ENSMUSG00000014776
	O60936
	Q9D1X0
NM_001185057; NM_001185058; NM_001276307; NM_001276309; NM_001276311;
	NM_001276312; NM_001276319; NM_003946
	NM_030152
NP_001171986; NP_001263236; NP_001263238; NP_001263240; NP_001263241;
	NP_001263248; NP_003937
	NP_084428
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleolar protein 3 is a protein that in humans is encoded by the NOL3 gene.

Nol3 has been shown to be induced in multiple cancer types and acts as a repressor of apoptosis leading to resistance and proliferation. Paradoxically, loss of Nol3 also leads to hematological disruption in mice resulting in a myeloproliferative neoplasm resembling primary myelofibrosis (PMF), and its deletion has also been detected in patient samples of PMF.