NOS1

NOS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4D1N, 4UCH, 4UH5, 4UH6, 4V3U, 5ADF, 5ADG, 5ADI, 5FVX, 5FVW, 5FVU, 5FVV
Identifiers
Aliases	NOS1, IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS, nitric oxide synthase 1
External IDs	OMIM: 163731; MGI: 97360; HomoloGene: 37327; GeneCards: NOS1; OMA:NOS1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	117,452,170 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	118,096,905 bp
RNA expression pattern
	Top expressed in
	body of tongue; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; muscle of thigh; ; Pons; ; gastrocnemius muscle; ; spinal ganglia; ; buccal mucosa cell; ; vastus lateralis muscle;
	Top expressed in
	anterior amygdaloid area; ; pontine nuclei; ; subiculum; ; digastric muscle; ; temporal muscle; ; mammillary body; ; dorsal tegmental nucleus; ; ventromedial nucleus; ; lateral hypothalamus; ; sternocleidomastoid muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transmembrane transporter binding; tetrahydrobiopterin binding; NADP binding; cadmium ion binding; FMN binding; metal ion binding; heme binding; oxidoreductase activity; scaffold protein binding; calmodulin binding; protein binding; sodium channel regulator activity; flavin adenine dinucleotide binding; arginine binding; nitric-oxide synthase activity; NADPH-hemoprotein reductase activity;
Cellular component	membrane; photoreceptor inner segment; T-tubule; synapse; ryanodine receptor complex; mitochondrion; perinuclear region of cytoplasm; caveola; cytoskeleton; cell projection; dendritic spine; Z discdkac; sarcoplasmic reticulum membrane; membrane raft; sarcoplasmic reticulum; sarcolemma; cytosol; cytoplasm; nucleoplasm; plasma membrane; protein-containing complex; calyx of Held; nucleus; vesicle membrane; postsynaptic density;
Biological process	multicellular organismal response to stress; positive regulation of guanylate cyclase activity; regulation of sodium ion transport; positive regulation of the force of heart contraction; negative regulation of hydrolase activity; striated muscle contraction; regulation of neurogenesis; negative regulation of serotonin uptake; positive regulation of transcription, DNA-templated; peptidyl-cysteine S-nitrosylation; cell redox homeostasis; arginine catabolic process; negative regulation of potassium ion transport; nitric oxide mediated signal transduction; negative regulation of calcium ion transport into cytosol; myoblast fusion; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; regulation of ryanodine-sensitive calcium-release channel activity; regulation of cardiac conduction; nitric oxide biosynthetic process; positive regulation of sodium ion transmembrane transport; cellular response to growth factor stimulus; neurotransmitter biosynthetic process; positive regulation of histone acetylation; negative regulation of calcium ion transport; regulation of cardiac muscle contraction; positive regulation of transcription by RNA polymerase II; response to hypoxia; response to heat; negative regulation of blood pressure; retrograde trans-synaptic signaling by nitric oxide; vasodilation; positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; synaptic signaling by nitric oxide; response to hormone; response to lipopolysaccharide; positive regulation of peptidyl-serine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	4842
	18125
	ENSG00000089250
	ENSMUSG00000029361
	P29475
	Q9Z0J4
	NM_000620; NM_001204213; NM_001204214; NM_001204218
	NM_008712
	NP_000611; NP_001191142; NP_001191143; NP_001191147
	NP_032738
	Wikidata
View/Edit Human	View/Edit Mouse

Nitric oxide synthase 1 (neuronal), also known as NOS1, is an enzyme that in humans is encoded by the NOS1 gene.