NOTCH3

NOTCH3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZLP, 5CZX, 5CZV
Identifiers
Aliases	NOTCH3, CADASIL, CASIL, IMF2, LMNS, CADASIL1, notch 3, notch receptor 3
External IDs	OMIM: 600276; MGI: 99460; HomoloGene: 376; GeneCards: NOTCH3; OMA:NOTCH3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	15,200,995 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	32,385,826 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; tibial arteries; ; right coronary artery; ; ventricular zone; ; Descending thoracic aorta; ; ascending aorta; ; left coronary artery; ; saphenous vein; ; skin of leg; ; stromal cell of endometrium;
	Top expressed in
	external carotid artery; ; corneal stroma; ; internal carotid artery; ; ankle joint; ; molar; ; vas deferens; ; Gonadal ridge; ; left lung lobe; ; lactiferous gland; ; carotid body;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein binding; enzyme binding; cadherin binding; identical protein binding; signaling receptor activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; Golgi membrane; receptor complex; plasma membrane; nucleoplasm; extracellular region; actin cytoskeleton; nucleus; cytosol; cell surface;
Biological process	Notch signaling pathway; cell differentiation; regulation of transcription, DNA-templated; negative regulation of neuron differentiation; negative regulation of cell differentiation; glomerular capillary formation; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; multicellular organism development; artery morphogenesis; forebrain development; neuron fate commitment; transcription initiation from RNA polymerase II promoter; positive regulation of transcription by RNA polymerase II; positive regulation of smooth muscle cell proliferation; regulation of developmental process; positive regulation of transcription of Notch receptor target; Notch receptor processing, ligand-dependent; negative regulation of Notch signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4854
	18131
	ENSG00000074181
	ENSMUSG00000038146
	Q9UM47
	Q61982
	NM_000435
	NM_008716
	NP_000426
	NP_032742
	Wikidata
View/Edit Human	View/Edit Mouse

Neurogenic locus notch homolog protein 3 (Notch 3) is a protein that in humans is encoded by the NOTCH3 gene.