NOV (gene)

CCN3
Identifiers
Aliases	CCN3, IBP-9, IGFBP-9, IGFBP9, NOVh, nephroblastoma overexpressed, cellular communication network factor 3, NOV
External IDs	OMIM: 164958; MGI: 109185; HomoloGene: 1884; GeneCards: CCN3; OMA:CCN3 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	119,424,434 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	54,617,435 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; adrenal cortex; ; left adrenal cortex; ; right adrenal gland; ; right adrenal cortex; ; ascending aorta; ; popliteal artery; ; tibial arteries; ; Descending thoracic aorta; ; saphenous vein;
	Top expressed in
	tunica media of zone of aorta; ; subiculum; ; ascending aorta; ; aortic valve; ; optic nerve; ; Region I of hippocampus proper; ; pineal gland; ; anterior amygdaloid area; ; suprachiasmatic nucleus; ; ankle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	insulin-like growth factor binding; Notch binding; integrin binding; protein binding; growth factor activity; heparin binding;
Cellular component	cytoplasm; intracellular membrane-bounded organelle; extracellular matrix; extracellular region; axon; soma; cell junction; dendrite; gap junction; collagen-containing extracellular matrix;
Biological process	fibroblast migration; hematopoietic stem cell homeostasis; negative regulation of insulin secretion; chondrocyte differentiation; negative regulation of sensory perception of pain; smooth muscle cell migration; negative regulation of SMAD protein signal transduction; endothelial cell-cell adhesion; negative regulation of chondrocyte proliferation; bone regeneration; negative regulation of monocyte chemotaxis; cell adhesion mediated by integrin; negative regulation of cell growth; regulation of cell growth; angiogenesis; endothelial cell chemotaxis; negative regulation of myotube differentiation; cell chemotaxis; regulation of gene expression; smooth muscle cell proliferation; negative regulation of inflammatory response; type B pancreatic cell proliferation; positive regulation of Notch signaling pathway; cell-cell signaling; negative regulation of cell death; regulation of signaling receptor activity; negative regulation of NIK/NF-kappaB signaling; cell adhesion; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	4856
	18133
	ENSG00000136999
	ENSMUSG00000037362
	P48745
	Q64299
	NM_002514
	NM_010930
	NP_002505
	NP_035060
	Wikidata
View/Edit Human	View/Edit Mouse

NOV (nephroblastoma overexpressed) also known as CCN3 is a matricellular protein that in humans is encoded by the NOV gene.