NPAS3

NPAS3
Identifiers
Aliases	NPAS3, neuronal PAS domain protein 3, MOP6, PASD6, bHLHe12
External IDs	OMIM: 609430; MGI: 1351610; HomoloGene: 8461; GeneCards: NPAS3; OMA:NPAS3 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	33,820,863 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	54,072,175 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; ventricular zone; ; corpus callosum; ; buccal mucosa cell; ; globus pallidus; ; internal globus pallidus; ; external globus pallidus; ; optic nerve; ; inferior ganglion of vagus nerve; ; entorhinal cortex;
	Top expressed in
	substantia nigra; ; lumbar subsegment of spinal cord; ; deep cerebellar nuclei; ; dorsal tegmental nucleus; ; fossa; ; globus pallidus; ; dorsomedial hypothalamic nucleus; ; ventral tegmental area; ; condyle; ; lateral hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein dimerization activity; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein heterodimerization activity;
Cellular component	nucleoplasm; cytosol; nucleus;
Biological process	regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription, DNA-templated; developmental process; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	64067
	27386
	ENSG00000151322
	ENSMUSG00000021010
	Q8IXF0
	Q9QZQ0
NM_001164749; NM_001165893; NM_022123; NM_173159; NM_001394988;
	NM_001394989
	NM_013780
	NP_001158221; NP_001159365; NP_071406; NP_775182
	NP_038808
	Wikidata
View/Edit Human	View/Edit Mouse

NPAS3 or Neuronal PAS domain protein 3 is a brain-enriched transcription factor belonging to the bHLH-PAS superfamily of transcription factors, the members of which carry out diverse functions, including circadian oscillations, neurogenesis, toxin metabolism, hypoxia, and tracheal development. NPAS3 contains basic helix-loop-helix structural motif and PAS domain, like the other proteins in the superfamily.