Neuropeptides B/W receptor 1

NPBWR1
Identifiers
Aliases	NPBWR1, GPR7, Neuropeptides B/W receptor 1, neuropeptides B and W receptor 1
External IDs	OMIM: 600730; MGI: 891989; HomoloGene: 21096; GeneCards: NPBWR1; OMA:NPBWR1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	52,943,734 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	5,987,617 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; gallbladder; ; olfactory zone of nasal mucosa; ; prefrontal cortex; ; right lobe of liver; ; cingulate gyrus; ; anterior cingulate cortex; ; Brodmann area 9; ; Hypothalamus;
	Top expressed in
	embryo; ; lip; ; Hypothalamus; ; hippocampus proper; ; dentate gyrus of hippocampal formation granule cell; ; zone of skin; ; tail of embryo; ; superior frontal gyrus; ; primary visual cortex; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled opioid receptor activity; neuropeptide binding; protein binding; G protein-coupled receptor activity; signal transducer activity; neuropeptide receptor activity; peptide binding;
Cellular component	integral component of membrane; neuron projection; plasma membrane; integral component of plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; regulation of metabolic process; neuropeptide signaling pathway; signal transduction; chemical synaptic transmission; G protein-coupled opioid receptor signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2831
	226304
	ENSG00000288611
	ENSMUSG00000033774
	P48145
	P49681
	NM_005285
	NM_010342
	NP_005276
	NP_034472
	Wikidata
View/Edit Human	View/Edit Mouse

Neuropeptides B/W receptor 1, also known as NPBW1 and GPR7, is a human protein encoded by the NPBWR1 gene. As implied by its name, it and related gene NPBW2 (with which it shares 70% nucleotide identity) are transmembranes protein that bind Neuropeptide B (NPB) and Neuropeptide W (NPW), both proteins expressed strongly in parts of the brain that regulate stress and fear including the extended amygdala and stria terminalis. When originally discovered in 1995, these receptors had no known ligands ("orphan receptors") and were called GPR7 and GPR8, but at least three groups in the early 2000s independently identified their endogenous ligands, triggering the name change in 2005.