Neuropeptide FF

NPFF
Identifiers
Aliases	NPFF, FMRFAL, neuropeptide FF-amide peptide precursor
External IDs	OMIM: 604643; MGI: 1891708; HomoloGene: 48236; GeneCards: NPFF; OMA:NPFF - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	53,507,484 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	102,433,377 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; epithelium of colon; ; granulocyte; ; ganglionic eminence; ; apex of heart; ; olfactory zone of nasal mucosa; ; C1 segment; ; stromal cell of endometrium; ; mucosa of transverse colon;
	Top expressed in
	bone marrow; ; pancreas; ; islet of Langerhans; ; adrenal gland; ; urinary bladder; ; skeletal muscle tissue; ; morula; ; zone of skin; ; white adipose tissue; ; spleen;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; G protein-coupled receptor binding; neuropeptide hormone activity;
Cellular component	vesicle; extracellular region; postsynapse; extracellular space; dendrite; perikaryon; axon terminus;
Biological process	negative regulation of insulin secretion; regulation of sensory perception of pain; maternal process involved in female pregnancy; positive regulation of cytosolic calcium ion concentration; acute inflammatory response to antigenic stimulus; negative regulation of appetite; vasopressin secretion; regulation of membrane depolarization; negative regulation of heart rate; response to morphine; positive regulation of blood pressure; spinal cord development; neuropeptide signaling pathway; somatostatin secretion; chemical synaptic transmission; excitatory postsynaptic potential; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8620
	54615
	ENSG00000139574
	ENSMUSG00000023052
	O15130
	Q9WVA8
	NM_003717; NM_001320296
	NM_018787
	NP_001307225; NP_003708
	NP_061257
	Wikidata
View/Edit Human	View/Edit Mouse

Neuropeptide FF (NPFF, FLFQPQRFa) is a mammalian amidated neuropeptide originally isolated from bovine brain and characterized as a pain-modulating peptide, with anti-opioid activity on morphine-induced analgesia.

In humans, neuropeptide FF peptides are encoded by the NPFF gene. Two genes encoding two different receptors (NPFF1 and NPFF2) and two precursors (NPFFA and NPFFB) have been cloned in several mammalian species.