Small heterodimer partner

NR0B2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YUC, 2Q3Y, 2Z4J, 4DOR, 4ONI
Identifiers
Aliases	NR0B2, SHP, SHP1, nuclear receptor subfamily 0 group B member 2
External IDs	OMIM: 604630; MGI: 1346344; HomoloGene: 8030; GeneCards: NR0B2; OMA:NR0B2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	26,913,975 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	133,283,847 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; duodenum; ; jejunal mucosa; ; body of pancreas; ; gonad; ; right adrenal gland; ; left adrenal gland; ; left adrenal cortex; ; right adrenal cortex; ; gallbladder;
	Top expressed in
	left lobe of liver; ; epithelium of stomach; ; adrenal medulla; ; morula; ; myocardium of ventricle; ; duodenum; ; right kidney; ; embryo; ; embryo; ; pyloric antrum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein homodimerization activity; protein domain specific binding; steroid hormone receptor activity; protein binding; transcription corepressor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein-containing complex binding; transcription factor binding; retinoic acid receptor binding; peroxisome proliferator activated receptor binding; retinoid X receptor binding; thyroid hormone receptor binding;
Cellular component	nucleoplasm; nucleus; cytoplasm; protein-containing complex;
Biological process	Notch signaling pathway; regulation of transcription, DNA-templated; cholesterol metabolic process; negative regulation of transcription by RNA polymerase II; response to glucose; negative regulation of DNA-binding transcription factor activity; negative regulation of gene expression; transcription, DNA-templated; positive regulation of gene expression; animal organ regeneration; transcription initiation from RNA polymerase II promoter; negative regulation of transcription, DNA-templated; positive regulation of insulin secretion; steroid hormone mediated signaling pathway; circadian rhythm; circadian regulation of gene expression; rhythmic process;
	Sources:Amigo / QuickGO
Orthologs
	8431
	23957
	ENSG00000131910
	ENSMUSG00000037583
	Q15466
	Q62227
	NM_021969
	NM_011850
	NP_068804
	NP_035980
	Wikidata
View/Edit Human	View/Edit Mouse

The small heterodimer partner (SHP) also known as NR0B2 (nuclear receptor subfamily 0, group B, member 2) is a protein that in humans is encoded by the NR0B2 gene. SHP is a member of the nuclear receptor family of intracellular transcription factors. SHP is unusual for a nuclear receptor in that it lacks a DNA binding domain. Therefore, it is technically neither a transcription factor nor nuclear receptor but nevertheless it is still classified as such due to relatively high sequence homology with other nuclear receptor family members.