Liver X receptor beta

NR1H2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1P8D, 1PQ6, 1PQ9, 1PQC, 1UPV, 1UPW, 3KFC, 3L0E, 4DK7, 4DK8, 4RAK, 5HJP, 4NQA, 5I4V,%%s4NQA
Identifiers
Aliases	NR1H2, LXR-b, LXRB, NER, NER-I, RIP15, UNR, Liver X receptor beta, nuclear receptor subfamily 1 group H member 2
External IDs	OMIM: 600380; MGI: 1352463; HomoloGene: 21397; GeneCards: NR1H2; OMA:NR1H2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	50,383,388 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	44,203,375 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; tibial arteries; ; right coronary artery; ; thoracic aorta; ; left coronary artery; ; ascending aorta; ; Descending thoracic aorta; ; gastric mucosa; ; gastrocnemius muscle; ; muscle of thigh;
	Top expressed in
	granulocyte; ; neural layer of retina; ; lip; ; muscle of thigh; ; right kidney; ; superior frontal gyrus; ; duodenum; ; thymus; ; esophagus; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; ATPase binding; zinc ion binding; DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding; retinoid X receptor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; steroid hormone receptor activity; apolipoprotein A-I receptor binding; nuclear receptor activity; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription cis-regulatory region binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription factor binding; nuclear receptor coactivator activity; signaling receptor activity;
Cellular component	cytoplasm; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex;
Biological process	positive regulation of high-density lipoprotein particle assembly; negative regulation of proteolysis; positive regulation of triglyceride biosynthetic process; positive regulation of protein metabolic process; negative regulation of interferon-gamma-mediated signaling pathway; positive regulation of cholesterol transport; regulation of transcription, DNA-templated; cellular lipid metabolic process; regulation of transcription by RNA polymerase II; positive regulation of secretion of lysosomal enzymes; positive regulation of lipid storage; positive regulation of lipoprotein lipase activity; negative regulation of transcription by RNA polymerase II; positive regulation of fatty acid biosynthetic process; negative regulation of gene expression; transcription, DNA-templated; positive regulation of transcription, DNA-templated; negative regulation of cholesterol storage; negative regulation of pinocytosis; positive regulation of gene expression; retinoic acid receptor signaling pathway; positive regulation of cholesterol efflux; positive regulation of pancreatic juice secretion; lipid homeostasis; negative regulation of lipid transport; transcription initiation from RNA polymerase II promoter; negative regulation of transcription, DNA-templated; negative regulation of macrophage derived foam cell differentiation; positive regulation of transcription by RNA polymerase II; steroid hormone mediated signaling pathway; cholesterol homeostasis; lipid metabolism; multicellular organism development; cell differentiation; cellular response to lipopolysaccharide; negative regulation of cold-induced thermogenesis; intracellular receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7376
	22260
	ENSG00000131408
	ENSMUSG00000060601
	P55055
	Q60644
	NM_007121; NM_001256647
	NM_001285517; NM_001285518; NM_001285519; NM_009473
	NP_001243576; NP_009052; NP_009052.3
	NP_001272446; NP_001272447; NP_001272448; NP_033499
	Wikidata
View/Edit Human	View/Edit Mouse

Liver X receptor beta (LXR-β) is a member of the nuclear receptor family of transcription factors. LXR-β is encoded by the NR1H2 gene (nuclear receptor subfamily 1, group H, member 2).