TLX

NR2E1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4XAJ
Identifiers
Aliases	NR2E1, TLL, TLX, XTLL, nuclear receptor subfamily 2 group E member 1
External IDs	OMIM: 603849; MGI: 1100526; HomoloGene: 37750; GeneCards: NR2E1; OMA:NR2E1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	108,188,805 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	42,459,628 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; secondary oocyte; ; ganglionic eminence; ; retinal pigment epithelium; ; caudate nucleus; ; internal globus pallidus; ; Amygdala; ; putamen; ; nucleus accumbens; ; entorhinal cortex;
	Top expressed in
	zygote; ; secondary oocyte; ; ventricular zone; ; primary oocyte; ; olfactory epithelium; ; medial ganglionic eminence; ; retinal pigment epithelium; ; male urethra; ; pretectal area; ; neural layer of retina;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; zinc ion binding; DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding; metal ion binding; steroid hormone receptor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding;
Cellular component	nucleoplasm; nucleus;
Biological process	glial cell migration; cell fate commitment; negative regulation of astrocyte differentiation; regulation of transcription, DNA-templated; negative regulation of neuron differentiation; somatic stem cell population maintenance; dentate gyrus development; negative regulation of neural precursor cell proliferation; regulation of cellular component organization; extracellular matrix organization; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; behavioral fear response; regulation of timing of neuron differentiation; transcription, DNA-templated; nervous system development; positive regulation of angiogenesis; anterior commissure morphogenesis; regulation of dendrite morphogenesis; positive regulation of neural precursor cell proliferation; multicellular organism development; brain development; positive regulation of cell cycle; amygdala development; retina development in camera-type eye; forebrain generation of neurons; layer formation in cerebral cortex; positive regulation of cell population proliferation; cerebral cortex development; social behavior; cerebral cortex neuron differentiation; regulation of cell migration involved in sprouting angiogenesis; camera-type eye development; olfactory bulb development; transcription initiation from RNA polymerase II promoter; positive regulation of stem cell proliferation; aggressive behavior; visual perception; steroid hormone mediated signaling pathway; positive regulation of transcription by RNA polymerase II; long-term potentiation;
	Sources:Amigo / QuickGO
Orthologs
	7101
	21907
	ENSG00000112333
	ENSMUSG00000019803
	Q9Y466
	Q64104
	NM_001286102; NM_003269
	NM_152229
	NP_001273031; NP_003260
	NP_689415
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear receptor TLX (homologue of the Drosophila tailless gene) also known as NR2E1 (Nuclear receptor subfamily 2 group E member 1) is a protein that in humans is encoded by the NR2E1 gene. TLX is a member of the nuclear receptor family of intracellular transcription factors.