V-erbA-related gene

NR2F6
Identifiers
Aliases	NR2F6, EAR-2, EAR2, ERBAL2, nuclear receptor subfamily 2 group F member 6
External IDs	OMIM: 132880; MGI: 1352453; HomoloGene: 7706; GeneCards: NR2F6; OMA:NR2F6 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	17,245,919 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	71,834,604 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; mucosa of transverse colon; ; nasal epithelium; ; jejunal mucosa; ; palpebral conjunctiva; ; right lobe of liver; ; mucosa of sigmoid colon; ; apex of heart; ; corpus epididymis; ; olfactory zone of nasal mucosa;
	Top expressed in
	right kidney; ; Paneth cell; ; proximal tubule; ; left lobe of liver; ; internal carotid artery; ; external carotid artery; ; choroid plexus of fourth ventricle; ; cumulus cell; ; somite; ; transitional epithelium of urinary bladder;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; zinc ion binding; nuclear receptor activity; DNA-binding transcription factor activity; DNA binding; protein binding; steroid hormone receptor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nucleus;
Biological process	transcription, DNA-templated; signal transduction; detection of temperature stimulus involved in sensory perception of pain; entrainment of circadian clock by photoperiod; negative regulation of transcription by RNA polymerase II; steroid hormone mediated signaling pathway; transcription initiation from RNA polymerase II promoter; neuron development; regulation of transcription, DNA-templated; intracellular receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2063
	13864
	ENSG00000160113
	ENSMUSG00000002393
	P10588
	P43136
	NM_005234
	NM_010150
	NP_005225; NP_005225.2
	NP_034280
	Wikidata
View/Edit Human	View/Edit Mouse

V-erbA-related protein 2 (EAR-2) also known as NR2F6 (nuclear receptor subfamily 2 group F member 6) is a protein that in humans is encoded by the NR2F6 gene. V-erbA-related protein 2 is a member of the nuclear receptor family of intracellular transcription factors. It is named after its similarity to v-erbA (P03373), a helper of an oncoprotein called v-erbB in avian erythroblastosis virus.