Germ cell nuclear factor

NR6A1
Identifiers
Aliases	NR6A1, CT150, GCNF, GCNF1, NR61, RTR, hGCNF, hRTR, nuclear receptor subfamily 6 group A member 1
External IDs	OMIM: 602778; MGI: 1352459; HomoloGene: 36308; GeneCards: NR6A1; OMA:NR6A1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	124,771,311 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	38,817,700 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; oocyte; ; secondary oocyte; ; buccal mucosa cell; ; right testis; ; left testis; ; sperm; ; left lobe of thyroid gland; ; right lobe of thyroid gland;
	Top expressed in
	primitive streak; ; spermatid; ; epiblast; ; seminiferous tubule; ; secondary oocyte; ; lumbar spinal ganglion; ; zygote; ; spermatocyte; ; primary oocyte; ; yolk sac;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; protein homodimerization activity; DNA-binding transcription factor activity; zinc ion binding; DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding; steroid hormone receptor activity; nuclear receptor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nucleus; transcription regulator complex;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; gamete generation; spermatogenesis; transcription initiation from RNA polymerase II promoter; cell population proliferation; positive regulation of transcription by RNA polymerase II; intracellular steroid hormone receptor signaling pathway; intracellular receptor signaling pathway; steroid hormone mediated signaling pathway; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	2649
	14536
	ENSG00000148200
	ENSMUSG00000063972
	Q15406
	Q64249
	NM_001278546; NM_001489; NM_033334; NM_033335
	NM_001159548; NM_001159549; NM_010264
	NP_001265475; NP_001480; NP_201591; NP_201591.2
	NP_001153020; NP_001153021; NP_034394
	Wikidata
View/Edit Human	View/Edit Mouse

The germ cell nuclear factor (GCNF), also known as RTR (retinoid receptor-related testis-associated receptor) or NR6A1 (nuclear receptor subfamily 6, group A, member 1), is a protein that in humans is encoded by the NR6A1 gene. GCNF is a member of the nuclear receptor family of intracellular transcription factors .

In adults, GCNH is expressed mainly in the germ cells of gonads and is involved in the regulation of embryogenesis and germ cell differentiation.

Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. The gene expresses three alternatively spliced transcript variants.

In cells undergoing homologous recombination during meiosis, DNA intermediates are processed as an essential step in the exchange of information between parental homologous chromosomes. In eukaryotes the RTR complex, which consists of a type IA topoisomerase, a RecQ helicase and the structural protein RMI1, is employed in processing DNA recombination intermediates.