Neuropilin 2

NRP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QQJ, 2QQK, 2QQL, 2QQO, 4QDQ, 4QDR, 4QDS, 5DN2
Identifiers
Aliases	NRP2, NP2, NPN2, PRO2714, VEGF165R2, neuropilin 2
External IDs	OMIM: 602070; MGI: 1100492; HomoloGene: 2875; GeneCards: NRP2; OMA:NRP2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	205,798,133 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	62,857,854 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; gastric mucosa; ; epithelium of colon; ; muscle layer of sigmoid colon; ; cartilage tissue; ; body of uterus; ; Achilles tendon; ; smooth muscle tissue; ; gallbladder; ; left ovary;
	Top expressed in
	calvaria; ; body of femur; ; habenula; ; epithelium of bronchiole; ; stroma of bone marrow; ; dermis; ; genital tubercle; ; olfactory tubercle; ; hair follicle; ; tail of embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	vascular endothelial growth factor-activated receptor activity; heparin binding; semaphorin receptor activity; growth factor binding; metal ion binding; cytokine binding; protein binding; identical protein binding; signaling receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; semaphorin receptor complex; extracellular region; axon; glutamatergic synapse; integral component of postsynaptic membrane;
Biological process	sympathetic ganglion development; cell differentiation; semaphorin-plexin signaling pathway involved in neuron projection guidance; positive regulation of endothelial cell proliferation; vascular endothelial growth factor signaling pathway; nervous system development; axon guidance; positive regulation of endothelial cell migration; multicellular organism development; sympathetic neuron projection guidance; vascular endothelial growth factor receptor signaling pathway; cell adhesion; angiogenesis; nerve development; sympathetic neuron projection extension; axon extension involved in axon guidance; outflow tract septum morphogenesis; neural crest cell migration; neuron migration; heart development; facial nerve structural organization; vestibulocochlear nerve structural organization; gonadotrophin-releasing hormone neuronal migration to the hypothalamus; ventral trunk neural crest cell migration; negative chemotaxis; trigeminal ganglion development; sensory neuron axon guidance; neural crest cell migration involved in autonomic nervous system development; facioacoustic ganglion development; dorsal root ganglion morphogenesis; cellular response to leukemia inhibitory factor; regulation of postsynapse organization; viral process;
	Sources:Amigo / QuickGO
Orthologs
	8828
	18187
	ENSG00000118257
	ENSMUSG00000025969
	O60462
	O35375
NM_003872; NM_018534; NM_201264; NM_201266; NM_201267;
	NM_201279
NM_001077403; NM_001077404; NM_001077405; NM_001077406; NM_001077407;
	NM_010939
NP_003863; NP_061004; NP_957716; NP_957718; NP_957719;
	NP_958436
NP_001070871; NP_001070872; NP_001070873; NP_001070874; NP_001070875;
	NP_035069
	Wikidata
View/Edit Human	View/Edit Mouse

Neuropilin 2 (NRP2) is a protein that in humans is encoded by the NRP2 gene.

This gene encodes a member of the neuropilin family of receptor proteins. NRP2 is expressed by a wide variety of cell types. The transmembrane protein has been reported to bind to SEMA3C, SEMA3F, VEGF-A, VEGF-C, VEGF-D, TGFβ, integrins and ANGPTL4 to promote downstream signaling pathways. Consequently, NRP2 is known to play a role in cardiovascular development, axon guidance, tumorigenesis, inflammation and cardiovascular disease. Multiple transcript variants encoding distinct isoforms have been identified for this gene.