NSDHL

NSDHL
Identifiers
Aliases	NSDHL, H105E3, SDR31E1, XAP104, NAD(P) dependent steroid dehydrogenase-like
External IDs	OMIM: 300275; MGI: 1099438; HomoloGene: 5951; GeneCards: NSDHL; OMA:NSDHL - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	152,869,729 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	72,002,120 bp
RNA expression pattern
	Top expressed in
	mucosa of esophagus; ; endothelial cell; ; gingival epithelium; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; mucosa of transverse colon; ; ganglionic eminence; ; gonad; ; right lobe of liver;
	Top expressed in
	left lobe of liver; ; efferent ductule; ; superior cervical ganglion; ; medial vestibular nucleus; ; transitional epithelium of urinary bladder; ; brown adipose tissue; ; dorsal tegmental nucleus; ; anterior horn of spinal cord; ; facial motor nucleus; ; endothelial cell of lymphatic vessel;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	3-beta-hydroxy-delta5-steroid dehydrogenase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity; oxidoreductase activity; C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity; 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity; 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; lipid droplet; membrane; endoplasmic reticulum;
Biological process	lipid metabolism; labyrinthine layer blood vessel development; smoothened signaling pathway; steroid metabolic process; hair follicle development; cholesterol metabolic process; cholesterol biosynthetic process; steroid biosynthetic process; sterol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	50814
	18194
	ENSG00000147383
	ENSMUSG00000031349
	Q15738
	Q9R1J0
	NM_001129765; NM_015922
	NM_010941
	NP_001123237; NP_057006
	NP_035071
	Wikidata
View/Edit Human	View/Edit Mouse

Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating is an enzyme that in humans is encoded by the NSDHL gene. This enzyme is localized in the endoplasmic reticulum and is involved in cholesterol biosynthesis.