NSFL1C

NSFL1C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SS6
Identifiers
Aliases	NSFL1C, P47, UBX1, UBXD10, UBXN2C, dJ776F14.1, NSFL1 cofactor
External IDs	OMIM: 606610; MGI: 3042273; HomoloGene: 41114; GeneCards: NSFL1C; OMA:NSFL1C - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	1,473,842 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	151,353,334 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; gastrocnemius muscle; ; left adrenal cortex; ; skin of leg; ; tibialis anterior muscle; ; skin of abdomen; ; retinal pigment epithelium; ; monocyte;
	Top expressed in
	tail of embryo; ; lens; ; neural layer of retina; ; genital tubercle; ; neural tube; ; Hypothalamus; ; yolk sac; ; olfactory bulb; ; ventricular zone; ; ovary;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	lipid binding; ubiquitin binding; protein binding; phospholipid binding; protein phosphatase regulator activity; ATPase binding;
Cellular component	Golgi stack; plasma membrane; Golgi apparatus; intermediate filament cytoskeleton; VCP-NSFL1C complex; nucleus; nucleoplasm; chromosome; cytosol; spindle pole centrosome; cytoplasm; microtubule organizing center; cytoskeleton;
Biological process	membrane fusion; nuclear membrane reassembly; Golgi organization; proteasome-mediated ubiquitin-dependent protein catabolic process; autophagosome assembly; regulation of phosphoprotein phosphatase activity; establishment of mitotic spindle orientation; positive regulation of mitotic centrosome separation; negative regulation of protein localization to centrosome;
	Sources:Amigo / QuickGO
Orthologs
	55968
	386649
	ENSG00000088833
	ENSMUSG00000027455
	Q9UNZ2
	Q9CZ44
	NM_001206736; NM_016143; NM_018839; NM_182483
	NM_001291074; NM_198326
	NP_001193665; NP_057227; NP_061327
	NP_001278003; NP_938085
	Wikidata
View/Edit Human	View/Edit Mouse

NSFL1 cofactor p47 is a protein that in humans is encoded by the NSFL1C gene.

N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Multiple transcript variants encoding several different isoforms have been found for this gene.