N-ethylmaleimide sensitive fusion protein

NSF
Identifiers
Aliases	NSF, SKD2, N-ethylmaleimide sensitive factor, N-ethylmaleimide sensitive factor, vesicle fusing ATPase, SEC18, DEE96
External IDs	OMIM: 601633; MGI: 104560; HomoloGene: 4502; GeneCards: NSF; OMA:NSF - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	46,757,464 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	103,844,882 bp
RNA expression pattern
	Top expressed in
	superior frontal gyrus; ; prefrontal cortex; ; primary visual cortex; ; Brodmann area 9; ; right frontal lobe; ; cerebellar cortex; ; anterior cingulate cortex; ; cerebellar hemisphere; ; nucleus accumbens; ; Hypothalamus;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; pontine nuclei; ; subiculum; ; medial dorsal nucleus; ; medial vestibular nucleus; ; dorsal tegmental nucleus; ; superior colliculus; ; medial geniculate nucleus; ; deep cerebellar nuclei; ; ventral tegmental area;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; PDZ domain binding; syntaxin-1 binding; metal ion binding; protein binding; syntaxin binding; hydrolase activity; ATP binding; protein kinase binding; SNARE binding; protein-containing complex binding; ionotropic glutamate receptor binding; ATPase activity;
Cellular component	postsynaptic density; myelin sheath; plasma membrane; dendritic shaft; lysosomal membrane; extracellular exosome; Golgi membrane; cytoplasm; cytosol; Golgi stack;
Biological process	plasma membrane fusion; positive regulation of protein catabolic process; regulation of exocytosis; potassium ion transport; endoplasmic reticulum to Golgi vesicle-mediated transport; COPII vesicle coating; protein transport; intracellular protein transport; vesicle-mediated transport; positive regulation of receptor recycling; exocytosis; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; SNARE complex disassembly; transport; Golgi to plasma membrane protein transport; Golgi vesicle docking;
	Sources:Amigo / QuickGO
Orthologs
	4905
	18195
	ENSG00000073969; ENSG00000278174; ENSG00000276262
	ENSMUSG00000034187
	P46459
	P46460
	NM_006178
	NM_008740
	NP_006169
	NP_032766
	Wikidata
View/Edit Human	View/Edit Mouse

N-ethylmaleimide-sensitive factor, also known as NSF or N-ethylmaleimide sensitive fusion proteins, is an enzyme which in humans is encoded by the NSF gene.