NT5C3

NT5C3A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CN1, 2JGA, 2VKQ
Identifiers
Aliases	NT5C3A, NT5C3, P5'N-1, P5N-1, PN-I, POMP, PSN1, UMPH, UMPH1, cN-III, hUMP1, p36, 5'-nucleotidase, cytosolic IIIA
External IDs	OMIM: 606224; MGI: 1927186; HomoloGene: 9534; GeneCards: NT5C3A; OMA:NT5C3A - orthologs
EC number	3.1.3.91
Gene location (Human)
Chr.	Chromosome 7 (human)
End	33,062,797 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	56,900,917 bp
RNA expression pattern
	Top expressed in
	quadriceps femoris muscle; ; monocyte; ; thymus; ; rectum; ; duodenum; ; gastrocnemius muscle; ; muscle of thigh; ; islet of Langerhans; ; mucosa of transverse colon; ; cerebellar vermis;
	Top expressed in
	blood; ; interventricular septum; ; islet of Langerhans; ; esophagus; ; right kidney; ; soleus muscle; ; left colon; ; spleen; ; temporal muscle; ; mucous cell of stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; 5'-nucleotidase activity; hydrolase activity; magnesium ion binding; metal ion binding; tRNA 2'-phosphotransferase activity;
Cellular component	cytoplasm; cytosol; endoplasmic reticulum;
Biological process	pyrimidine nucleoside metabolic process; adenosine metabolic process; nucleotide metabolic process; pyrimidine nucleoside catabolic process; dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	51251
	107569
	ENSG00000122643
	ENSMUSG00000029780
	Q9H0P0
	Q9D020
	NM_001002009; NM_001002010; NM_001166118; NM_016489; NM_001356996
	NM_001252374; NM_026004; NM_001360963
NP_001002009; NP_001002010; NP_001159590; NP_057573; NP_001343925;
	NP_001361264; NP_001361265; NP_001361266; NP_001361267; NP_001361268
	NP_001239303; NP_080280; NP_001347892
	Wikidata
View/Edit Human	View/Edit Mouse

Cytosolic 5'-nucleotidase 3 (NT5C3), also known as cytosolic 5'-nucleotidase 3A, pyrimidine 5’-nucleotidase (PN-I or P5'NI), and p56, is an enzyme that in humans is encoded by the NT5C3, or NT5C3A, gene on chromosome 7.

This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. Mutations in this gene are a cause of hemolytic anemia due to uridine 5-prime monophosphate hydrolase deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and pseudogenes of this gene are located on the long arm of chromosomes 3 and 4. [provided by RefSeq, Mar 2012]