NT5M

NT5M
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MH9, 1Q91, 1Q92, 1Z4I, 1Z4J, 1Z4K, 1Z4L, 1Z4M, 1Z4P, 1Z4Q, 2JAU, 2JAW, 4L6A, 4L6C, 4MUM, 4MWO, 4NFL, 4YIK
Identifiers
Aliases	NT5M, dNT-2, dNT2, mdN, 5',3'-nucleotidase, mitochondrial
External IDs	OMIM: 605292; MGI: 1917127; HomoloGene: 10622; GeneCards: NT5M; OMA:NT5M - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	17,347,663 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	59,771,794 bp
RNA expression pattern
	Top expressed in
	monocyte; ; gonad; ; apex of heart; ; muscle of thigh; ; right frontal lobe; ; anterior cingulate cortex; ; gastrocnemius muscle; ; testicle; ; left testis; ; right testis;
	Top expressed in
	spermatocyte; ; interventricular septum; ; seminiferous tubule; ; spermatid; ; dentate gyrus of hippocampal formation granule cell; ; facial motor nucleus; ; visual cortex; ; primary visual cortex; ; nucleus of stria terminalis; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; nucleotidase activity; 5'-nucleotidase activity; hydrolase activity; metal ion binding;
Cellular component	mitochondrial matrix; mitochondrion;
Biological process	pyrimidine deoxyribonucleotide catabolic process; DNA replication; dUMP catabolic process; deoxyribonucleotide catabolic process; nucleotide metabolic process; pyrimidine nucleoside catabolic process; dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	56953
	103850
	ENSG00000205309
	ENSMUSG00000032615
	Q9NPB1
	Q8VCE6
	NM_020201
	NM_134029
	NP_064586
	NP_598790
	Wikidata
View/Edit Human	View/Edit Mouse

5',3'-nucleotidase, mitochondrial, also known as 5'(3')-deoxyribonucleotidase, mitochondrial (mdN) or deoxy-5'-nucleotidase 2 (dNT-2), is an enzyme that in humans is encoded by the NT5M gene. This gene encodes a 5' nucleotidase that localizes to the mitochondrial matrix. This enzyme dephosphorylates the 5'- and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides. The gene is located within the Smith–Magenis syndrome region on chromosome 17.