NUDT12

NUDT12
Identifiers
Aliases	NUDT12, nudix hydrolase 12
External IDs	OMIM: 609232; MGI: 1915243; HomoloGene: 44188; GeneCards: NUDT12; OMA:NUDT12 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	103,562,790 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	59,320,367 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; jejunal mucosa; ; rectum; ; Achilles tendon; ; testicle; ; body of pancreas; ; right adrenal cortex; ; vastus lateralis muscle; ; mucosa of paranasal sinus; ; left adrenal gland;
	Top expressed in
	left lobe of liver; ; brown adipose tissue; ; intercostal muscle; ; human kidney; ; Epithelium of choroid plexus; ; right kidney; ; lobe of prostate; ; adrenal gland; ; white adipose tissue; ; proximal tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	NAD+ diphosphatase activity; protein binding; hydrolase activity; metal ion binding; NADH pyrophosphatase activity;
Cellular component	cytoplasm; peroxisome; nucleus; peroxisomal matrix; cytosol;
Biological process	NAD catabolic process; NADP catabolic process; NAD biosynthesis via nicotinamide riboside salvage pathway; NADH metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	83594
	67993
	ENSG00000112874
	ENSMUSG00000024228
	Q9BQG2
	Q9DCN1
	NM_001300741; NM_031438
	NM_026497; NM_001368393
	NP_001287670; NP_113626
	NP_080773; NP_001355322
	Wikidata
View/Edit Human	View/Edit Mouse

Peroxisomal NADH pyrophosphatase NUDT12 is an enzyme that in humans is encoded by the NUDT12 gene.

Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors.

Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003).[supplied by OMIM]