NUDT3

NUDT3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FVV, 2Q9P
Identifiers
Aliases	NUDT3, DIPP, DIPP-1, DIPP1, nudix hydrolase 3
External IDs	OMIM: 609228; MGI: 1928484; HomoloGene: 31400; GeneCards: NUDT3; OMA:NUDT3 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	34,392,669 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	27,842,469 bp
RNA expression pattern
	Top expressed in
	dorsal motor nucleus of vagus nerve; ; inferior olivary nucleus; ; postcentral gyrus; ; Brodmann area 46; ; Brodmann area 10; ; middle frontal gyrus; ; Region I of hippocampus proper; ; lateral nuclear group of thalamus; ; external globus pallidus; ; entorhinal cortex;
	Top expressed in
	neural layer of retina; ; perirhinal cortex; ; entorhinal cortex; ; CA3 field; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; superior frontal gyrus; ; central gray substance of midbrain; ; cingulate gyrus; ; primary motor cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity; inositol diphosphate tetrakisphosphate diphosphatase activity; inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity; hydrolase activity; diphosphoinositol-polyphosphate diphosphatase activity; inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity; metal ion binding; inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity; inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity; magnesium ion binding; inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity; inositol diphosphate pentakisphosphate diphosphatase activity; inositol bisdiphosphate tetrakisphosphate diphosphatase activity; endopolyphosphatase activity; bis(5'-adenosyl)-hexaphosphatase activity; bis(5'-adenosyl)-pentaphosphatase activity; m7G(5')pppN diphosphatase activity;
Cellular component	nucleus; cytoplasm; cytosol;
Biological process	cell-cell signaling; diadenosine polyphosphate catabolic process; inositol phosphate metabolic process; diphosphoinositol polyphosphate catabolic process; diadenosine pentaphosphate catabolic process; diadenosine hexaphosphate catabolic process; adenosine 5'-(hexahydrogen pentaphosphate) catabolic process; diphosphoinositol polyphosphate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	11165
	56409
	ENSG00000272325
	ENSMUSG00000024213
	O95989
	Q9JI46
	NM_006703
	NM_001291046; NM_019837
	NP_006694
	NP_001277975; NP_062811
	Wikidata
View/Edit Human	View/Edit Mouse

Diphosphoinositol polyphosphate phosphohydrolase 1 is an enzyme that in humans is encoded by the NUDT3 gene.

NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998).[supplied by OMIM]