NUDT4

NUDT4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DUK
Identifiers
Aliases	NUDT4, DIPP2, DIPP2alpha, DIPP2beta, HDCMB47P, nudix hydrolase 4, DIPP-2B, NUDT4B
External IDs	OMIM: 609229; MGI: 1918457; HomoloGene: 41726; GeneCards: NUDT4; OMA:NUDT4 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	93,408,146 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	95,400,008 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; parotid gland; ; myocardium of left ventricle; ; renal medulla; ; caput epididymis; ; corpus epididymis; ; cardiac muscle tissue of right atrium; ; gallbladder; ; trabecular bone; ; mucosa of sigmoid colon;
	Top expressed in
	molar; ; ciliary body; ; endocardial cushion; ; submandibular gland; ; left colon; ; granulocyte; ; seminiferous tubule; ; atrium; ; quadriceps femoris muscle; ; knee joint;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	inositol diphosphate tetrakisphosphate diphosphatase activity; inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity; inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity; inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity; metal ion binding; protein binding; RNA binding; inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity; hydrolase activity; diphosphoinositol-polyphosphate diphosphatase activity; inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity; inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity; inositol diphosphate pentakisphosphate diphosphatase activity; inositol bisdiphosphate tetrakisphosphate diphosphatase activity; endopolyphosphatase activity; bis(5'-adenosyl)-hexaphosphatase activity; bis(5'-adenosyl)-pentaphosphatase activity; m7G(5')pppN diphosphatase activity; snoRNA binding;
Cellular component	intracellular anatomical structure; nucleus; cytoplasm; cytosol;
Biological process	intracellular signal transduction; cyclic nucleotide metabolic process; inositol phosphate metabolic process; cyclic-nucleotide-mediated signaling; calcium-mediated signaling; diphosphoinositol polyphosphate metabolic process; diadenosine pentaphosphate catabolic process; diadenosine hexaphosphate catabolic process; adenosine 5'-(hexahydrogen pentaphosphate) catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	11163
	71207
	ENSG00000173598
	ENSMUSG00000020029
	Q9NZJ9
	Q8R2U6
	NM_001301022; NM_001301023; NM_001301024; NM_019094; NM_199040
	NM_027722; NM_001358996
	NP_001287951; NP_001287952; NP_001287953; NP_061967; NP_950241
	NP_081998; NP_001345925
	Wikidata
View/Edit Human	View/Edit Mouse

Diphosphoinositol polyphosphate phosphohydrolase 2 is an enzyme that in humans is encoded by the NUDT4 gene.

The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing.