NUDT5

NUDT5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DSB, 2DSC, 2DSD, 3AC9, 3ACA, 3BM4, 3L85
Identifiers
Aliases	NUDT5, YSA1, YSA1H, YSAH1, hYSAH1, nudix hydrolase 5, hNUDT5
External IDs	OMIM: 609230; MGI: 1858232; HomoloGene: 5388; GeneCards: NUDT5; OMA:NUDT5 - orthologs
EC number	3.6.1.58
Gene location (Human)
Chr.	Chromosome 10 (human)
End	12,196,144 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	5,871,895 bp
RNA expression pattern
	Top expressed in
	gonad; ; right lobe of liver; ; ganglionic eminence; ; rectum; ; stromal cell of endometrium; ; gingival epithelium; ; islet of Langerhans; ; mucosa of ileum; ; ventricular zone; ; anterior pituitary;
	Top expressed in
	otic placode; ; gastrula; ; embryo; ; epiblast; ; embryo; ; primary oocyte; ; primitive streak; ; abdominal wall; ; medullary collecting duct; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	m7G(5')pppN diphosphatase activity; hydrolase activity; magnesium ion binding; metal ion binding; nucleoside-diphosphatase activity; RNA binding; ADP-sugar diphosphatase activity; snoRNA binding; 8-oxo-dGDP phosphatase activity; protein binding; transferase activity; ADP-ribose diphosphatase activity; protein homodimerization activity; nucleotidyltransferase activity;
Cellular component	cytosol; extracellular exosome; intracellular anatomical structure; nucleus;
Biological process	nucleobase-containing small molecule catabolic process; ribonucleoside diphosphate catabolic process; nucleobase-containing compound metabolic process; nucleotide metabolic process; D-ribose catabolic process; chromatin remodeling; ATP generation from poly-ADP-D-ribose; nucleoside phosphate metabolic process; ribose phosphate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	11164
	53893
	ENSG00000165609
	ENSMUSG00000025817
	Q9UKK9
	Q9JKX6
	NM_014142; NM_001321647; NM_001321648
	NM_016918
	NP_001308576; NP_001308577; NP_054861
	NP_058614
	Wikidata
View/Edit Human	View/Edit Mouse

ADP-sugar pyrophosphatase is an enzyme that in humans is encoded by the NUDT5 gene.

Nudix hydrolases, such as NUDT5, eliminate toxic nucleotide derivatives from the cell and regulate the levels of important signaling nucleotides and their metabolites (McLennan, 1999).[supplied by OMIM]