NUDT6

NUDT6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3FXT, 3H95
Identifiers
Aliases	NUDT6, ASFGF2, FGF-AS, FGF2AS, GFG-1, GFG1, nudix hydrolase 6
External IDs	OMIM: 606261; MGI: 2387618; HomoloGene: 31425; GeneCards: NUDT6; OMA:NUDT6 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	122,922,968 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	37,474,360 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; internal globus pallidus; ; right lobe of liver; ; germinal epithelium; ; oocyte; ; left ventricle; ; right adrenal gland; ; right adrenal cortex; ; right ventricle; ; left adrenal gland;
	Top expressed in
	interventricular septum; ; aortic valve; ; ascending aorta; ; right kidney; ; muscle of thigh; ; proximal tubule; ; masseter muscle; ; myocardium of ventricle; ; skeletal muscle tissue; ; sternocleidomastoid muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	growth factor activity; hydrolase activity; NADH pyrophosphatase activity; ADP-ribose diphosphatase activity; NAD binding;
Cellular component	cytoplasm; mitochondrion; nucleus; cellular component;
Biological process	regulation of signaling receptor activity; biological process; negative regulation of cell population proliferation; negative regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	11162
	229228
	ENSG00000170917
	ENSMUSG00000050174
	P53370
	Q8CH40
	NM_198041; NM_007083
	NM_001291044; NM_153561
	NP_009014; NP_932158
	NP_001277973; NP_705789
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleoside diphosphate-linked moiety X motif 6 is a protein that in humans is encoded by the NUDT6 gene.

FGF2 (MIM 134920) is a highly conserved, multifunctional heparin-binding growth factor involved in neuroectoderm development, angiogenesis, and wound healing.

Elevated levels of FGF2 are associated with proliferation of smooth muscle in atherosclerosis and with proliferation of tumors. The FGF2 antisense gene, NUDT6, may regulate FGF2 expression.[supplied by OMIM]