Nucleoporin 50

NUP50
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EC1, 3TJ3
Identifiers
Aliases	NUP50, NPAP60, NPAP60L, nucleoporin 50kDa, nucleoporin 50
External IDs	OMIM: 604646; MGI: 1351502; HomoloGene: 5190; GeneCards: NUP50; OMA:NUP50 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	45,188,017 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	84,827,164 bp
RNA expression pattern
	Top expressed in
	epithelium of nasopharynx; ; nasal epithelium; ; mucosa of paranasal sinus; ; bone marrow; ; bone marrow cells; ; endothelial cell; ; trabecular bone; ; Epithelium of choroid plexus; ; blood; ; sperm;
	Top expressed in
	Ileal epithelium; ; zygote; ; seminiferous tubule; ; primitive streak; ; spermatid; ; secondary oocyte; ; epiblast; ; tail of embryo; ; genital tubercle; ; yolk sac;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; GTPase activator activity;
Cellular component	nuclear membrane; membrane; nucleoplasm; nucleus; intracellular membrane-bounded organelle; nuclear pore; cytoplasm; centrosome; host cell;
Biological process	mRNA transport; intracellular transport; protein transport; viral process; protein import into nucleus; mRNA export from nucleus; positive regulation of GTPase activity; regulation of glycolytic process; tRNA export from nucleus; protein sumoylation; viral transcription; regulation of gene silencing by miRNA; intracellular transport of virus; regulation of cellular response to heat;
	Sources:Amigo / QuickGO
Orthologs
	10762
	18141
	ENSG00000093000
	ENSMUSG00000016619
	Q9UKX7
	Q9JIH2
	NM_007172; NM_153645; NM_153684
	NM_016714
	NP_009103; NP_705931
	NP_057923
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleoporin 50 (Nup50) is a protein that in humans is encoded by the NUP50 gene.

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene.