NUPR1

NUPR1
Identifiers
Aliases	NUPR1, COM1, P8, nuclear protein 1, transcriptional regulator
External IDs	OMIM: 614812; MGI: 1891834; HomoloGene: 8229; GeneCards: NUPR1; OMA:NUPR1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	28,539,008 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,230,033 bp
RNA expression pattern
	Top expressed in
	left lobe of thyroid gland; ; right lobe of thyroid gland; ; body of pancreas; ; right adrenal cortex; ; gastric mucosa; ; left adrenal cortex; ; muscle layer of sigmoid colon; ; skin of abdomen; ; skin of leg; ; right lung;
	Top expressed in
	submandibular gland; ; epithelium of lens; ; lacrimal gland; ; calvaria; ; crypt of lieberkuhn of small intestine; ; tunica media of zone of aorta; ; ascending aorta; ; epithelium of stomach; ; parotid gland; ; pyloric antrum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	chromatin binding; DNA binding; protein binding; transcription coactivator activity; acetyltransferase activator activity;
Cellular component	nucleus; cytosol; protein-DNA complex; cytoplasm; perinuclear region of cytoplasm;
Biological process	skeletal muscle cell differentiation; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of cell cycle; male gonad development; regulation of transcription, DNA-templated; acute inflammatory response; negative regulation of fibroblast proliferation; regulation of female gonad development; response to toxic substance; transcription, DNA-templated; protein acetylation; positive regulation of protein modification process; positive regulation of apoptotic process; regulation of transcription by RNA polymerase II; cell population proliferation; protein-containing complex assembly; negative regulation of cell population proliferation; positive regulation of catalytic activity; positive regulation of proteasomal protein catabolic process; positive regulation of nucleic acid-templated transcription; regulation of autophagy; negative regulation of autophagy; negative regulation of cardiac muscle cell apoptotic process; negative regulation of apoptotic process; negative regulation of DNA-binding transcription factor activity; positive regulation of neuron apoptotic process; negative regulation of glycolytic process; negative regulation of epithelial cell proliferation; negative regulation of programmed necrotic cell death; positive regulation of neuroinflammatory response; negative regulation of autophagosome assembly; positive regulation of oxidative phosphorylation; negative regulation of epithelial cell apoptotic process; negative regulation of type B pancreatic cell proliferation; regulation of response to endoplasmic reticulum stress; positive regulation of intrinsic apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	26471
	56312
	ENSG00000176046
	ENSMUSG00000030717
	O60356
	Q9WTK0
	NM_012385; NM_001042483
	NM_019738
	NP_001035948; NP_036517
	NP_062712
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear protein 1 is a protein that in humans is encoded by the NUPR1 gene.