Naphyrone

Naphyrone
Clinical data
Other names	O-2482; Naphthylpyrovalerone
ATC code	none;
Legal status
Legal status	DE: Anlage II (Authorized trade only, not prescriptible); UK: Class B; US: Schedule I; Poland: I-P;
Identifiers
	IUPAC name (RS)-1-naphthalen-2-yl-2-pyrrolidin-1-ylpentan-1-one;
CAS Number	850352-53-3 ; 850352-11-3 (hydrochloride);
PubChem CID	11243002;
ChemSpider	9418039;
UNII	96ON64182B;
CompTox Dashboard (EPA)	DTXSID301014192 ;
Chemical and physical data
Formula	C19H23NO
Molar mass	281.399 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCC(C(C1=CC2=C(C=C1)C=CC=C2)=O)N3CCCC3;

Naphyrone, also known as O-2482 and naphthylpyrovalerone, is a stimulant drug of the cathinone and naphthylaminopropane families. It was derived from pyrovalerone and acts as a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI). Naphyrone has been reported as a novel designer drug. No safety or toxicity data is available on the drug.

The drug has been marketed under the name “NRG-1,” although only a minority of samples of substances sold under this name have been found to actually contain naphyrone, and even samples that proved to contain genuine β-naphyrone were in some cases also found to contain the 1-naphthyl isomer α-naphyrone in varying proportions, further confusing the reported effects profile.