Natriuretic peptide precursor C

NPPC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JDP
Identifiers
Aliases	NPPC, CNP, CNP2, Natriuretic peptide precursor C, natriuretic peptide C
External IDs	OMIM: 600296; MGI: 97369; HomoloGene: 7867; GeneCards: NPPC; OMA:NPPC - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	231,926,396 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	86,598,293 bp
RNA expression pattern
	Top expressed in
	testicle; ; C1 segment; ; prefrontal cortex; ; Brodmann area 9; ; apex of heart; ; anterior cingulate cortex; ; right hemisphere of cerebellum; ; olfactory zone of nasal mucosa; ; left ventricle; ; Hypothalamus;
	Top expressed in
	lumbar subsegment of spinal cord; ; embryo; ; embryo; ; morula; ; lip; ; superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; cumulus cell; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; hormone activity; peptide hormone receptor binding; signaling receptor binding; hormone receptor binding;
Cellular component	secretory granule; extracellular region; extracellular space; protein-containing complex;
Biological process	animal organ development; negative regulation of meiotic cell cycle; regulation of cardiac conduction; growth plate cartilage chondrocyte proliferation; response to hypoxia; ossification; regulation of multicellular organism growth; negative regulation of oocyte maturation; growth plate cartilage chondrocyte differentiation; post-embryonic development; receptor guanylyl cyclase signaling pathway; regulation of smooth muscle cell proliferation; cGMP biosynthetic process; positive regulation of osteoblast differentiation; negative regulation of DNA metabolic process; response to ethanol; negative regulation of cell population proliferation; protein folding; regulation of signaling receptor activity; reproductive process; cGMP-mediated signaling; positive regulation of cGMP-mediated signaling; negative regulation of collagen biosynthetic process; negative regulation of DNA biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	4880
	18159
	ENSG00000163273
	ENSMUSG00000026241
	P23582
	Q61839
	NM_024409
	NM_010933
	NP_077720
	NP_035063
	Wikidata
View/Edit Human	View/Edit Mouse

Natriuretic peptide precursor C, also known as NPPC, is a protein that in humans is encoded by the NPPC gene. The precursor NPPC protein is cleaved to the 22 amino acid peptide C-type natriuretic peptide (CNP).