Nav1.8

SCN10A
Identifiers
Aliases	SCN10A, FEPS2, Nav1.8, PN3, SNS, hPN3, sodium voltage-gated channel alpha subunit 10
External IDs	OMIM: 604427; MGI: 108029; HomoloGene: 21300; GeneCards: SCN10A; OMA:SCN10A - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	38,816,286 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	119,548,388 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; tibialis anterior muscle; ; mucosa of ileum; ; lower lobe of lung; ; deltoid muscle; ; spinal ganglia; ; skin of hip; ; trigeminal ganglion; ; skin of thigh; ; gonad;
	Top expressed in
	spinal ganglia; ; trigeminal ganglion; ; primary oocyte; ; embryonic cell; ; zygote; ; secondary oocyte; ; glossopharyngeal ganglion; ; spinal cord; ; neural tube; ; heart;
	More reference expression data
	n/a
Gene ontology
Molecular function	voltage-gated sodium channel activity; ion channel activity; transmembrane transporter binding; sodium channel activity; voltage-gated ion channel activity;
Cellular component	integral component of membrane; voltage-gated sodium channel complex; membrane; clathrin complex; extracellular exosome; plasma membrane; axon; glutamatergic synapse; integral component of presynaptic membrane;
Biological process	bundle of His cell action potential; sodium ion transmembrane transport; transmembrane transport; neuronal action potential; regulation of heart rate; regulation of atrial cardiac muscle cell membrane depolarization; membrane depolarization during action potential; sensory perception of pain; regulation of ion transmembrane transport; ion transport; regulation of cardiac muscle contraction; AV node cell action potential; sodium ion transport; odontogenesis of dentin-containing tooth; sensory perception; regulation of postsynaptic membrane potential; transport;
	Sources:Amigo / QuickGO
Orthologs
	6336
	20264
	ENSG00000185313
	ENSMUSG00000034533
	Q9Y5Y9
	Q6QIY3
	NM_001293306; NM_001293307; NM_006514
	NM_001205321; NM_009134
	NP_001280235; NP_001280236; NP_006505
	NP_001192250; NP_033160
	Wikidata
View/Edit Human	View/Edit Mouse

Na_v1.8 is a sodium ion channel subtype that in humans is encoded by the SCN10A gene.

Na_v1.8-containing channels are tetrodotoxin (TTX)-resistant voltage-gated channels. Na_v1.8 is expressed specifically in the dorsal root ganglion (DRG), in unmyelinated, small-diameter sensory neurons called C-fibres, and is involved in nociception. C-fibres can be activated by noxious thermal or mechanical stimuli and thus can carry pain messages.

The specific location of Na_v1.8 in sensory neurons of the DRG may make it a key therapeutic target for the development of new analgesics and the treatment of chronic pain.