Neomycin/polymyxin B/bacitracin

Neomycin/polymyxin B/bacitracin, also known as triple antibiotic ointment, and sold under the brand name Neosporin, among others, is an antibiotic medication used to reduce the risk of infections following minor skin injuries. It contains the three antibiotics neomycin, polymyxin B, and bacitracin. It is for topical use.

Possible side effects include itchiness and skin rash, and in rare cases hearing loss. It is relatively broad spectrum, being effective against both Gram-negative and Gram-positive bacteria.

The combination is available over the counter in the US and Canada. In 2021, it was the 376th most commonly prescribed medication in the United States, with more than 25,000 prescriptions.