Nerve growth factor

NGF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZBN, 1SG1, 1WWW, 2IFG, 4EDW, 4EDX
Identifiers
Aliases	NGF, Beta-HSAN5, NGFB, nerve growth factor
External IDs	OMIM: 162030; MGI: 97321; HomoloGene: 1876; GeneCards: NGF; OMA:NGF - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	115,338,770 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	102,428,329 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; left uterine tube; ; right auricle of heart; ; right ovary; ; apex of heart; ; ascending aorta; ; left ovary; ; tibial arteries; ; left ventricle; ; Descending thoracic aorta;
	Top expressed in
	submandibular gland; ; right ventricle; ; embryo; ; genital tubercle; ; endothelial cell of lymphatic vessel; ; dentate gyrus of hippocampal formation granule cell; ; embryo; ; skin of lower limb; ; right kidney; ; middle ear;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; enzyme inhibitor activity; protein binding; metalloendopeptidase inhibitor activity; nerve growth factor receptor binding; growth factor activity; signaling receptor binding;
Cellular component	endosome; Golgi lumen; extracellular region; cytoplasmic vesicle; extracellular space; cytosol; synaptic vesicle; axon; dendrite;
Biological process	negative regulation of neuron apoptotic process; regulation of neuron differentiation; neuron projection morphogenesis; negative regulation of peptidase activity; neurotrophin TRK receptor signaling pathway; cell-cell signaling; negative regulation of apoptotic process; regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of axonogenesis; positive regulation of gene expression; positive regulation of apoptotic process; nerve growth factor processing; extrinsic apoptotic signaling pathway via death domain receptors; phosphatidylinositol-mediated signaling; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; microtubule-based movement; activation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of Ras protein signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; peripheral nervous system development; memory; negative regulation of cell population proliferation; regulation of signaling receptor activity; nerve development; nerve growth factor signaling pathway; positive regulation of DNA binding; positive regulation of neuron differentiation; positive regulation of collateral sprouting; modulation of chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	4803
	18049
	ENSG00000134259
	ENSMUSG00000027859
	P01138
	P01139
	NM_002506
	NM_001112698; NM_013609
	NP_002497
	NP_001106168; NP_038637
	Wikidata
View/Edit Human	View/Edit Mouse

Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is perhaps the prototypical growth factor, in that it was one of the first to be described. Since it was first isolated by Nobel laureates Rita Levi-Montalcini and Stanley Cohen in 1954, numerous biological processes involving NGF have been identified, two of them being the survival of pancreatic beta cells and the regulation of the immune system.