Neuronal calcium sensor-1

NCS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4GUK, 1G8I, 2LCP, 5AER, 5AFP, 5AEQ
Identifiers
Aliases	NCS1, FLUP, FREQ, neuronal calcium sensor 1
External IDs	OMIM: 603315; MGI: 109166; HomoloGene: 5719; GeneCards: NCS1; OMA:NCS1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	130,237,303 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	31,186,001 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; anterior cingulate cortex; ; nucleus accumbens; ; Amygdala; ; dorsolateral prefrontal cortex; ; postcentral gyrus; ; Brodmann area 9; ; prefrontal cortex; ; caudate nucleus; ; hippocampus proper;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; nucleus accumbens; ; medial geniculate nucleus; ; subiculum; ; medial dorsal nucleus; ; dorsomedial hypothalamic nucleus; ; olfactory tubercle; ; primary visual cortex; ; cerebellar cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; voltage-gated calcium channel activity; metal ion binding; protein binding; magnesium ion binding; protein kinase binding; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels;
Cellular component	cytoplasm; cytosol; postsynaptic membrane; Golgi apparatus; membrane; postsynaptic density; intracellular membrane-bounded organelle; plasma membrane; synapse; axon; cell junction; dendrite; perinuclear region of cytoplasm; dense core granule; cytoplasmic vesicle; calyx of Held; postsynapse; glutamatergic synapse; presynaptic cytosol; postsynaptic cytosol;
Biological process	regulation of neuron projection development; calcium ion transmembrane transport; positive regulation of exocytosis; phosphatidylinositol-mediated signaling; regulation of synaptic vesicle exocytosis; regulation of presynaptic cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Orthologs
	23413
	14299
	ENSG00000107130
	ENSMUSG00000062661
	P62166
	Q8BNY6
	NM_014286; NM_001128826
	NM_019681
	NP_001122298; NP_055101
	NP_062655
	Wikidata
View/Edit Human	View/Edit Mouse

Neuronal calcium sensor-1 (NCS-1) also known as frequenin homolog (Drosophila) (freq) is a protein that is encoded by the FREQ gene in humans. NCS-1 is a member of the neuronal calcium sensor family, a class of EF hand containing calcium-myristoyl-switch proteins.