Neuropeptide B

NPB
Identifiers
Aliases	NPB, L7, PPL7, PPneuropeptide B
External IDs	OMIM: 607996; MGI: 2387153; HomoloGene: 102151; GeneCards: NPB; OMA:NPB - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	81,902,905 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	120,499,919 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; testicle; ; Hypothalamus; ; substantia nigra; ; nucleus accumbens; ; Amygdala; ; stromal cell of endometrium; ; Brodmann area 9; ; putamen; ; anterior cingulate cortex;
	Top expressed in
	stomach; ; embryo; ; testicle; ; morula; ; embryo; ; right kidney; ; spermatid; ; placenta; ; urinary bladder; ; cerebellar cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; G protein-coupled receptor binding;
Cellular component	extracellular region;
Biological process	neuropeptide signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	256933
	208990
	ENSG00000183979
	ENSMUSG00000044034
	Q8NG41
	Q8K4P1
	NM_148896
	NM_153288; NM_001347616; NM_001347617
	NP_683694
	NP_001334545; NP_001334546; NP_695020
	Wikidata
View/Edit Human	View/Edit Mouse

Neuropeptide B is a short biologically active peptide whose precursor in humans is encoded by the NBP gene. Neuropeptide B acts via two G protein-coupled receptors, neuropeptide B/W receptors, called NPBW1 and NPBW2 encoded by the genes NPBWR1 and NPBWR2, respectively. Neuropeptide B is thought to be associated with the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. It is expressed throughout the central nervous system with high levels in the substantia nigra, hypothalamus, hippocampus, and spinal cord.