Neuropeptide S receptor

NPSR1
Identifiers
Aliases	NPSR1, ASRT2, GPR154, GPRA, NPSR, PGR14, VRR1, neuropeptide S receptor 1
External IDs	OMIM: 608595; MGI: 2441738; HomoloGene: 45515; GeneCards: NPSR1; OMA:NPSR1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	34,878,332 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	24,227,694 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; ganglionic eminence; ; Hypothalamus; ; prefrontal cortex; ; mucosa of transverse colon; ; anterior cingulate cortex; ; ventricular zone; ; Brodmann area 9; ; rectum;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; primary visual cortex; ; superior frontal gyrus; ; Hypothalamus; ; neural layer of retina; ; hippocampus proper; ; thymus; ; lens; ; olfactory bulb;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; vasopressin receptor activity; signal transducer activity; neuropeptide receptor activity;
Cellular component	cytoplasm; integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	positive regulation of release of sequestered calcium ion into cytosol; neuropeptide signaling pathway; signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	387129
	319239
	ENSG00000187258
	ENSMUSG00000043659
	Q6W5P4
	Q8BZP8
	NM_207173; NM_001300933; NM_001300934; NM_001300935; NM_207172
	NM_175678
	NP_001287862; NP_001287863; NP_001287864; NP_997055; NP_997056
	NP_783609
	Wikidata
View/Edit Human	View/Edit Mouse

The neuropeptide S receptor (NPSR) is a member of the G-protein coupled receptor superfamily of integral membrane proteins which binds neuropeptide S (NPS). It was formerly an orphan receptor, GPR154, until the discovery of neuropeptide S as the endogenous ligand. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. This gene is a member of the G protein-coupled receptor 1 family and encodes a plasma membrane protein. Mutations in this gene have also been associated with this disease.