Neurotensin

NTS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LNE, 2LNF, 2LNG, 2LYW, 3F6K, 2OYV, 2OYW, 4PO7
Identifiers
Aliases	NTS, NMN-125, NN, NT, NT/N, NTS1, neurotensin
External IDs	OMIM: 162650; MGI: 1328351; HomoloGene: 4506; GeneCards: NTS; OMA:NTS - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	85,882,992 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	102,326,347 bp
RNA expression pattern
	Top expressed in
	nasal epithelium; ; olfactory zone of nasal mucosa; ; mucosa of ileum; ; lateral nuclear group of thalamus; ; Hypothalamus; ; epithelium of bronchus; ; bronchial epithelial cell; ; lymph node; ; anterior pituitary; ; mucosa of paranasal sinus;
	Top expressed in
	ileum; ; intestinal villus; ; lateral hypothalamus; ; epithelium of small intestine; ; nucleus of stria terminalis; ; jejunum; ; nucleus accumbens; ; facial motor nucleus; ; lateral septal nucleus; ; anterior horn of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	neuropeptide hormone activity; protein binding;
Cellular component	extracellular region; transport vesicle; cytoplasmic vesicle; axon terminus;
Biological process	signal transduction; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4922
	67405
	ENSG00000133636
	ENSMUSG00000019890
	Q6FH20; P30990
	Q9D3P9
	NM_006183
	NM_024435
	NP_006174.1; NP_006174
	NP_077755
	Wikidata
View/Edit Human	View/Edit Mouse

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Neurotensin/neuromedin N precursor
Neurotensin/neuromedin N precursor
Identifiers
Symbol	Pro-NT_NN
Pfam	PF07421
InterPro	IPR008055
OPM superfamily	257
OPM protein	2oyv
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Neurotensin
Identifiers

CAS Number	39379-15-2^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:7542
ChemSpider	17290409^N
PubChem CID	16133836
UNII	XHB61LG5QS^Y
InChI InChI=1S/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)/t43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1^N Key: PCJGZPGTCUMMOT-ISULXFBGSA-N^N InChI=1/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)/t43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1
SMILES CC[C@H](C)[C@@H](/C(=N/[C@@H](CC(C)C)C(=O)O)/O)/N=C(/[C@H](Cc1ccc(cc1)O)/N=C(/[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)/N=C(/[C@H](CCCNC(=N)N)/N=C(/[C@@H]3CCCN3C(=O)[C@H](CCCCN)/N=C(/[C@H](CC(=N)O)/N=C(/[C@H](CCC(=O)O)/N=C(/[C@H](Cc4ccc(cc4)O)/N=C(\[C@H](CC(C)C)/N=C(\[C@@H]5CCC(=N5)O)/O)/O)\O)\O)\O)\O)\O)\O)\O
Properties
Chemical formula	C₇₈H₁₂₁N₂₁O₂₀
Molar mass	1672.92
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references

Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system. Neurotensin was first isolated from extracts of bovine hypothalamus based on its ability to cause a visible vasodilation in the exposed cutaneous regions of anesthetized rats.

Neurotensin is distributed throughout the central nervous system, with highest levels in the hypothalamus, amygdala and nucleus accumbens. It induces a variety of effects, including analgesia, hypothermia, and increased locomotor activity. It is also involved in regulation of dopamine pathways. In the periphery, neurotensin is found in enteroendocrine cells of the small intestine, where it leads to pancreatic and biliary secretion, reduced gastric acid secretion, and smooth muscle contraction.