Nirmatrelvir

Nirmatrelvir
Clinical data
Pronunciation	/nɜːrˈmætrəlvɪər/; nur-MAT-rəl-veer or /ˌnɜːrməˈtrɛlvɪər/; NUR-mə-TREL-veer
Other names	PF-07321332
License data	US DailyMed: Nirmatrelvir;
Pregnancy; category	AU: B3;
Routes of; administration	By mouth
ATC code	None;
Legal status
Legal status	CA: ℞-only;
Identifiers
	IUPAC name (1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;
CAS Number	2628280-40-8;
PubChem CID	155903259;
DrugBank	DB16691;
ChemSpider	114826566;
UNII	7R9A5P7H32;
KEGG	D12244;
ChEBI	CHEBI:170007;
CompTox Dashboard (EPA)	DTXSID501336829 ;
Chemical and physical data
Formula	C23H32F3N5O4
Molar mass	499.535 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	192.9 °C (379.2 °F)
	SMILES CC1([C@@H]2[C@H]1[C@H](N(C2)C(=O)[C@H](C(C)(C)C)NC(=O)C(F)(F)F)C(=O)N[C@@H](C[C@@H]3CCNC3=O)C#N)C;
	InChI InChI=1S/C23H32F3N5O4/c1-21(2,3)16(30-20(35)23(24,25)26)19(34)31-10-13-14(22(13,4)5)15(31)18(33)29-12(9-27)8-11-6-7-28-17(11)32/h11-16H,6-8,10H2,1-5H3,(H,28,32)(H,29,33)(H,30,35)/t11-,12-,13-,14-,15-,16+/m0/s1; Key:LIENCHBZNNMNKG-OJFNHCPVSA-N;

Nirmatrelvir is an antiviral medication developed by Pfizer which acts as an orally active 3C-like protease inhibitor. It is part of a nirmatrelvir/ritonavir combination used to treat COVID-19 and sold under the brand name Paxlovid.

Clinical data

Pronunciation	/nɜːrˈmætrəlvɪər/ nur-MAT-rəl-veer or /ˌnɜːrməˈtrɛlvɪər/ NUR-mə-TREL-veer
Other names	PF-07321332
License data	US DailyMed: Nirmatrelvir
Pregnancy category	AU: B3
Routes of administration	By mouth
ATC code	None
Legal status
Legal status	CA: ℞-only
Identifiers
IUPAC name (1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
CAS Number	2628280-40-8
PubChem CID	155903259
DrugBank	DB16691
ChemSpider	114826566
UNII	7R9A5P7H32
KEGG	D12244
ChEBI	CHEBI:170007
CompTox Dashboard (EPA)	DTXSID501336829
Chemical and physical data
Formula	C₂₃H₃₂F₃N₅O₄
Molar mass	499.535 g·mol⁻¹
3D model (JSmol)	Interactive image
Melting point	192.9 °C (379.2 °F)
SMILES CC1([C@@H]2[C@H]1[C@H](N(C2)C(=O)[C@H](C(C)(C)C)NC(=O)C(F)(F)F)C(=O)N[C@@H](C[C@@H]3CCNC3=O)C#N)C
InChI InChI=1S/C23H32F3N5O4/c1-21(2,3)16(30-20(35)23(24,25)26)19(34)31-10-13-14(22(13,4)5)15(31)18(33)29-12(9-27)8-11-6-7-28-17(11)32/h11-16H,6-8,10H2,1-5H3,(H,28,32)(H,29,33)(H,30,35)/t11-,12-,13-,14-,15-,16+/m0/s1 Key:LIENCHBZNNMNKG-OJFNHCPVSA-N