Nonsteroidal antiandrogen
| Nonsteroidal antiandrogen | |
|---|---|
| Drug class | |
Bicalutamide, the most widely used nonsteroidal antiandrogen and the most widely used antiandrogen in prostate cancer. | |
| Class identifiers | |
| Synonyms | Nonsteroidal androgen receptor antagonists |
| Use | Prostate cancer; Acne; Hirsutism; Seborrhea; Pattern hair loss; Hyperandrogenism; Transgender hormone therapy; Male precocious puberty; Priapism |
| ATC code | L02BB |
| Biological target | Androgen receptor |
| Chemical class | Nonsteroidal |
| Legal status | |
| In Wikidata | |
A nonsteroidal antiandrogen (NSAA) is an antiandrogen with a nonsteroidal chemical structure. They are typically selective and full or silent antagonists of the androgen receptor (AR) and act by directly blocking the effects of androgens like testosterone and dihydrotestosterone (DHT). NSAAs are used in the treatment of androgen-dependent conditions in men and women. They are the converse of steroidal antiandrogens (SAAs), which are antiandrogens that are steroids and are structurally related to testosterone.