Nuciferine

Nuciferine
Names
	IUPAC name 1,2-Dimethoxy-6aβ-aporphine
	Systematic IUPAC name (6aR)-1,2-Dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
	Other names (R)-1,2-Dimethoxyaporphine
Identifiers
CAS Number	475-83-2 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL464529 ;
ChemSpider	9740 ;
PubChem CID	10146;
UNII	W26UEB90B7 ;
CompTox Dashboard (EPA)	DTXSID40963862 ;
	InChI InChI=1S/C19H21NO2/c1-20-9-8-13-11-16(21-2)19(22-3)18-14-7-5-4-6-12(14)10-15(20)17(13)18/h4-7,11,15H,8-10H2,1-3H3/t15-/m1/s1 Key: ORJVQPIHKOARKV-OAHLLOKOSA-N ; InChI=1/C19H21NO2/c1-20-9-8-13-11-16(21-2)19(22-3)18-14-7-5-4-6-12(14)10-15(20)17(13)18/h4-7,11,15H,8-10H2,1-3H3/t15-/m1/s1 Key: ORJVQPIHKOARKV-OAHLLOKOBA;
	SMILES CN(CC1)[C@]2([H])CC3=CC=CC=C3C4=C2C1=CC(OC)=C4OC;
Properties
Chemical formula	C19H21NO2
Molar mass	295.376 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Nuciferine is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera.

Preliminary psychopharmacological research in 1978 was unable to conclusively determine the compound's classification regarding dopamine-receptor activity. On one hand, investigative studies found evidence of behavior traditionally associated with dopamine-receptor stimulation: stereotypy, increase in spontaneous motor activity, inhibition of conditioned avoidance response, and an increase in pain sensitivity resulting in an inhibition of morphine analgesia. On the other hand, these early investigative studies also found evidence of behavior traditionally associated with dopamine-receptor blockade: decrease of spontaneous motor activity, chills, catalepsy, trance-like states of consciousness.

Nuciferine exhibits a receptor profile similar to atypical antipsychotics, demonstrating antipsychotic-like effects in rodent models without inducing catalepsy.