Nuclear receptor 4A1

NR4A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QW4, 3V3E, 3V3Q, 4JGV, 4KZI, 4KZJ, 4KZM, 4RZE, 4RZF, 4RZG, 4RE8, 4REE, 4REF, 4WHF, 4WHG
Identifiers
Aliases	NR4A1, GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3, nuclear receptor subfamily 4 group A member 1, NH41
External IDs	OMIM: 139139; MGI: 1352454; HomoloGene: 1612; GeneCards: NR4A1; OMA:NR4A1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	52,059,507 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	101,172,676 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; left uterine tube; ; gallbladder; ; left ovary; ; tibial nerve; ; popliteal artery; ; tibial arteries; ; right ovary; ; muscle of thigh; ; vena cava;
	Top expressed in
	granulocyte; ; adrenal gland; ; plantaris muscle; ; triceps brachii muscle; ; vastus lateralis muscle; ; tibialis anterior muscle; ; extensor digitorum longus muscle; ; muscle of thigh; ; parotid gland; ; medial head of gastrocnemius muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; zinc ion binding; DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding; steroid hormone receptor activity; nuclear receptor activity; protein binding; protein heterodimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; glucocorticoid receptor binding;
Cellular component	nuclear membrane; nucleoplasm; nucleus; cytoplasm; cytosol; transcription regulator complex;
Biological process	regulation of transcription, DNA-templated; positive regulation of endothelial cell proliferation; negative regulation of cell cycle; cellular response to fibroblast growth factor stimulus; transcription, DNA-templated; cell migration involved in sprouting angiogenesis; endothelial cell chemotaxis; cellular response to corticotropin-releasing hormone stimulus; cellular response to vascular endothelial growth factor stimulus; transcription initiation from RNA polymerase II promoter; fat cell differentiation; regulation of type B pancreatic cell proliferation; signal transduction; steroid hormone mediated signaling pathway; positive regulation of transcription by RNA polymerase II; intracellular receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3164
	15370
	ENSG00000123358
	ENSMUSG00000023034
	P22736
	P12813
	NM_001202233; NM_001202234; NM_002135; NM_173157; NM_173158
	NM_010444
NP_001189162; NP_001189163; NP_002126; NP_775180; NP_002126.2;
	NP_775180.1
	NP_034574
	Wikidata
View/Edit Human	View/Edit Mouse

The nuclear receptor 4A1 (NR4A1 for "nuclear receptor subfamily 4 group A member 1") also known as Nur77, TR3, and NGFI-B is a protein that in humans is encoded by the NR4A1 gene.

Nuclear receptor 4A1 (NR4A1) is a member of the NR4A nuclear receptor family of intracellular transcription factors. NR4A1 is involved in cell cycle mediation, inflammation and apoptosis.

Nuclear receptor 4A1 plays a key role in mediating inflammatory responses in macrophages. In addition, subcellular localization of the NR4A1 protein appears to play a key role in the survival and death of cells.

Expression is inducible by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple alternatively spliced variants, encoding the same protein, have been identified.