O-1812

O-1812
Identifiers
	IUPAC name (5Z,8Z,11Z,14Z)-20-cyano-N-[(2R)-1-hydroxypropan-2-yl]-16,16-dimethylicosa-5,8,11,14-tetraenamide;
CAS Number	342882-77-3 ;
PubChem CID	9823107;
IUPHAR/BPS	732;
ChemSpider	7998855 ;
UNII	5766D7AFA7;
CompTox Dashboard (EPA)	DTXSID80745442 ;
Chemical and physical data
Formula	C26H42N2O2
Molar mass	414.634 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@H](CO)NC(=O)CCC/C=C\C/C=C\C/C=C\C/C=C\C(C)(C)CCCCC#N;
	InChI InChI=1S/C26H42N2O2/c1-24(23-29)28-25(30)19-15-12-10-8-6-4-5-7-9-11-13-16-20-26(2,3)21-17-14-18-22-27/h4-5,8-11,16,20,24,29H,6-7,12-15,17-19,21,23H2,1-3H3,(H,28,30)/b5-4-,10-8-,11-9-,20-16-/t24-/m1/s1 ; Key:WZQHSBKOWZOASP-QLZKPENWSA-N ;
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O-1812 is an eicosanoid derivative related to anandamide that acts as a potent and highly selective agonist for the cannabinoid receptor CB₁, with a K_i of 3.4 nM at CB₁ and 3870 nM at CB₂. Unlike most related compounds, O-1812 is metabolically stable against rapid breakdown by enzymes, and produces a cannabinoid-like discriminative effect in rats, which is similar but not identical to that produced by cannabinoid drugs of other chemical classes.

Identifiers

IUPAC name (5Z,8Z,11Z,14Z)-20-cyano-N-[(2R)-1-hydroxypropan-2-yl]-16,16-dimethylicosa-5,8,11,14-tetraenamide
CAS Number	342882-77-3^Y
PubChem CID	9823107
IUPHAR/BPS	732
ChemSpider	7998855^N
UNII	5766D7AFA7
CompTox Dashboard (EPA)	DTXSID80745442
Chemical and physical data
Formula	C₂₆H₄₂N₂O₂
Molar mass	414.634 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C[C@H](CO)NC(=O)CCC/C=C\C/C=C\C/C=C\C/C=C\C(C)(C)CCCCC#N
InChI InChI=1S/C26H42N2O2/c1-24(23-29)28-25(30)19-15-12-10-8-6-4-5-7-9-11-13-16-20-26(2,3)21-17-14-18-22-27/h4-5,8-11,16,20,24,29H,6-7,12-15,17-19,21,23H2,1-3H3,(H,28,30)/b5-4-,10-8-,11-9-,20-16-/t24-/m1/s1^N Key:WZQHSBKOWZOASP-QLZKPENWSA-N^N
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